3.5.3 Cell proliferation and differentiation
Genes involved in cell proliferation and differentiation, including
specifically for neuronal differentiation and neurogenesis were mostly
positively correlated with CO2 treatment and behaviours
in the CNS (Table 3). Genes involved in neuronal differentiation
(ttc3), neural stem cell self-renewal (srrt), neural
progenitor proliferation (melk), and neurogenesis (ncaph,
adgrb3) were all positively correlated with CO2 treatment and activity traits. Bcar3, which promotes cell
proliferation, migration and redistribution of actin fibres, and psap, which acts as a neurotrophic and myelinotrophic factor,
were negatively correlated with CO2 treatment and
positively correlated with number of exploratory interactions in the
CNS. Several cdk10 transcripts were identified as correlated with
CO2-induced behavioural change. Cdk10 codes for a
protein kinase that plays pivotal roles in controlling a range of
fundamental cellular processes including cell proliferation and
neurogenesis (reviewed in Guen et al. (2017)).