3.5.3 Cell proliferation and differentiation
Genes involved in cell proliferation and differentiation, including specifically for neuronal differentiation and neurogenesis were mostly positively correlated with CO2 treatment and behaviours in the CNS (Table 3). Genes involved in neuronal differentiation (ttc3), neural stem cell self-renewal (srrt), neural progenitor proliferation (melk), and neurogenesis (ncaph, adgrb3) were all positively correlated with COtreatment and activity traits. Bcar3, which promotes cell proliferation, migration and redistribution of actin fibres, and psap, which acts as a neurotrophic and myelinotrophic factor, were negatively correlated with CO2 treatment and positively correlated with number of exploratory interactions in the CNS. Several cdk10 transcripts were identified as correlated with CO2-induced behavioural change. Cdk10 codes for a protein kinase that plays pivotal roles in controlling a range of fundamental cellular processes including cell proliferation and neurogenesis (reviewed in Guen et al. (2017)).