Application of IgE PRS
Since IgE demonstrated genetic correlation between asthma and atopic dermatitis, indicated the pleiotropy effect of these regions and the highly shared genetic components between IgE and these two diseases. To reveal how the risk of higher IgE may relate to asthma and atopic dermatitis, we evaluated the association between IgE PRS and the risk status of these diseases (Figure 3b ) in another testing group. The top decile showed significant higher risk in asthma (OR= 1.11, 95% CI = 1.03-1.20, p = 0.006) and atopic dermatitis (OR = 1.06, 95%CI = 1.01-1.11, p = 0.027) compared with the bottom 9 deciles. In BBJ, we observed the consistent association between IgE PRS with asthma (OR = 1.10, 95% CI = 1.03-1.18, p = 0.006). For atopic dermatitis, the trend remained positive (OR = 1.02) but no statistics significance (p = 0.832).