Local genetic correlation
Local Analysis of [co]Variant Association (LAVA)23was used to find the potential loci of genetic correlation between two
diseases. Since global SNP genetic correlation (rg)
represented the mean of local correlations in the genome, there is the
possibility that opposing local genetic correlations are masked. To
explore the local genetic correlation between IgE and atopic disease, we
applied LAVA to conduct the analysis. The regions with p <
0.05 in univariate local genetic analysis was submitted to bivariate
analysis. We applied 1000 genome EAS as the reference panel. We defined
FDR < 0.05 as a significant threshold.