Figure legends:
Figure 1. Genome-wide association study for serum IgE level in a
Taiwanese Han population. The Manhattan plot (a) and the
quantile-quantile plot (b) of the IgE GWAS.
Figure 2. Pathway analysis and the genetic correlation results.(a) The top 20 enriched pathways were shown. (b) The global genetic
correlation between IgE and BBJ. Only the results with p <
0.05 were shown (c) The q value of the local genetic correlation between
IgE and allergic diseases (asthma and atopic dermatitis) were shown. The
red dashed line represented q value =0.05.
Figure 3. Comparison the risk among different strata of IgE
polygenetic risk score (PRS) for IgE and allergic disease. The error
bar represented standard deviation. (a) The quantile plot showed the
odds ratio (OR) for each stratum of IgE PRS percentile compared with the
median IgE PRS group. (b) The OR of allergic disease among top 10%
compared with the bottom 90% of the IgE PRS group. The top 10% IgE PRS
group showed significant higher risk for asthma in both CMUH and BBJ.
CMUH, China Medical University Hospital; BBJ, Biobank Japan. AD, atopic
dermatitis.