Sample Collection
The study design was shown in supplementary figure 1. Overall, 17,884 individuals were included in this study and 7,468 (41.8%) were men (Table 1 ). The mean age is 42.1 ± 20.7, and the mean age of male and female was 43.03 ± 19.49 and 40.72 ± 22.17, respectively. Most of the included individuals (76.4%) have at least one of the following diseases: allergic rhinitis, asthma, dermatitis, or urticaria. Some of them received at least one therapy that may influence the serum IgE level (n = 3,161).