Heritability estimation & Genetic correlation
The average heritability was estimated using the LD score (LDSC)21. We downloaded the summary statistics from Biobank Japan (BBJ)22. In order to update the genome build from Hg19 to GRCh38, we applied liftover to the summary statistics of BBJ. Furthermore, we used LDSC to conduct the genetic correlation (r g) between IgE and BBJ phenotypes21. The significant threshold was defined asP  < 0.002, according to the Bonferroni correction (0.05/165).