Results
A total of 8 independent variants showed genome-wide significance, and
rs147642819 at 6p21.32 was the most significant signal (p=
1.8×10-19). Seven of the loci were replicated
successfully after a meta-analysis of the Japanese population. Among all
the HLA alleles, HLA-DQB1*03:03 is the most significant allele.
The global genetic correlation showed significance between IgE and
asthma. The IgE PRS significantly correlated with the total IgE level.
Furthermore, the top 10 quantile IgE PRS group had a potentially higher
risk for asthma, which was replicated in the Japanese population as
well.