Pathway analysis
We mapped SNPs with p < 1×10-6 to the
closest genes and generate a list contained 128 genes (S Table
3 ). These genes were used to perform the pathway analysis. The top 20
significant pathways were shown in Figure 2a (S Table 4) . The
most significantly enriched pathway is the antigen presentation pathway
(q value = 2.55×10-19), which included HLA-A ,HLA-B , HLA-C , HLA-DOB , HLA-DQA1 ,HLA-DQA2 , HLA-DQB1 , HLA-DQB2 , HLA-DRA ,HLA-DRB1 , HLA-F , HLA-G , and TAP2 . The PD-1,
PD-L1 cancer immunotherapy pathway and the type 2 T helper pathway (Th2)
were also significantly enriched.