Pathway analysis
To identify genes that could be involved in the regulation of the serum IgE level, we mapped 1,384 variants that passed a threshold of suggested significance (p < 1x 10-6) to the genes. We further used Ingenuity Pathway Analysis (IPA) to conduct the canonical pathway analysis. To eliminate multiple test errors, the false discovery rate (FDR) q value < 0.05 was defined as significant.