PRS Construction
We used the 70% (n= 12,520) samples to calculate training GWAS (S Figure 3 ). After utilized PRS-CS to generate the posterior of variants, a total of 766,640 SNPs were included to generate the PRS. We further utilized the remaining 30% (n= 5,364) target data to generate IgE PRS for each individual. The IgE PRS was positively correlated with serum IgE level (Spearman’s rank correlation coefficient = 0.08, p = 1.59 ×10-8). From the strata plot, there was a positive trend that higher percentile revealed potentially higher OR of IgE level compared with the reference quantile (Figure 3a ).