Methods
Genome-wide association study was used to discover the association between variants and IgE. Through HLA imputation, we explored the association between HLA alleles and IgE. In order to explore the pleiotropy relationship between IgE and atopic diseases, we performed both global and local genetic correlation analysis. Moreover, we divided our cohort into a training group and a validation group to construct the polygenic risk score (PRS) of IgE and applied it to test the risk of asthma and atopic dermatitis.