Heritability estimation & Genetic correlation
The average heritability was estimated using the LD score
(LDSC)21. We downloaded the summary statistics from
Biobank Japan (BBJ)22. In order to update the genome
build from Hg19 to GRCh38, we applied liftover to the summary statistics
of BBJ. Furthermore, we used LDSC to conduct the genetic
correlation (r g) between IgE and BBJ
phenotypes21. The significant threshold was defined asP < 0.002, according to the Bonferroni correction
(0.05/165).