Evaluation of IgE PRS for the Risk of Asthma & Atopic
Dermatitis
To reduce potential bias, the samples within the IgE GWAS training set
were excluded from the following analysis. We test the association
between the case-control status of atopic diseases (asthma and atopic
dermatitis) in the top decile (10%) IgE PRS with the rest of 9 deciles
(bottom 90%) IgE PRS population under a logistic regression model. Age,
sex, and PC1 to PC10 were included as covariant. To explore the
application of our IgE PRS, we further applied our IgE PRS in the BBJ
population. We applied the posterior obtained from PRS-CS to construct
the PRS of individuals in BBJ and replicate the association test in
asthma & atopic dermatitis. We used 748,819 SNP which is common between
BBJ and Taiwan SNP list as PRS input. A total 748,370 variants were
processed for the calculation pf IgE PRS. The age, sex, 46 disease
status at registry, and PC1 to PC 10 were included as covariates.