Evaluation of IgE PRS for the Risk of Asthma & Atopic Dermatitis
To reduce potential bias, the samples within the IgE GWAS training set were excluded from the following analysis. We test the association between the case-control status of atopic diseases (asthma and atopic dermatitis) in the top decile (10%) IgE PRS with the rest of 9 deciles (bottom 90%) IgE PRS population under a logistic regression model. Age, sex, and PC1 to PC10 were included as covariant. To explore the application of our IgE PRS, we further applied our IgE PRS in the BBJ population. We applied the posterior obtained from PRS-CS to construct the PRS of individuals in BBJ and replicate the association test in asthma & atopic dermatitis. We used 748,819 SNP which is common between BBJ and Taiwan SNP list as PRS input. A total 748,370 variants were processed for the calculation pf IgE PRS. The age, sex, 46 disease status at registry, and PC1 to PC 10 were included as covariates.