Methods
Genome-wide association study was used to discover the association
between variants and IgE. Through HLA imputation, we explored the
association between HLA alleles and IgE. In order to explore the
pleiotropy relationship between IgE and atopic diseases, we performed
both global and local genetic correlation analysis. Moreover, we divided
our cohort into a training group and a validation group to construct the
polygenic risk score (PRS) of IgE and applied it to test the risk of
asthma and atopic dermatitis.