Genetic correlation
A total of 165 traits from the Biobank Japan project were included in
the genetic correlation analysis (S Table 5 ). The p-value less
than 0.05 were shown in Figure 2b. Asthma showed a significant
positive genetic correlation with IgE level (rg = 0.5,
SE = 0.14, p-value = 5×10-4) even after Bonferroni
correction (p < 3.7×10-4). On the other
hand, the atopic dermatitis did not show significant result
(rg = 0.27, p = 0.09). Except for the genetic
correlation on a genome-wide scale, we further explore the local
pleiotropy among IgE and atopic diseases (S Table 6 ). A total
of seven significant local genetic correlation signals with q-value
< 0.05 were founded between IgE and asthma (Figure
2c ), among them, 5 were within chr6 including 6p21.32, 6p21.33,
6q23.3-q23.2, and 6p24.1. The cytoband-16p12.1 showed the strongest
local genetic correlation between IgE and Asthma (rg=0.81, q-value =
2×10-4). We also observed one local genetic
correlation of 5q31.1 between IgE and AD (rg = 0.79,
q-value = 0.04) even though the global genetic correlation did not show
any significance.