Fig.4
The upper limits of
GM test and BDG assay are 0.5 and
37.5 (pg/ml) respectively.
The negative result of BDG assay is labelled as 37.5((pg/ml) in Table.
Pain(1: No pain;2:Mild pain,need no painkiller;3: Moderate pain, need
painkiller;4:Severe pain,poor effective of painkiller)
O :Operation
V :Treatment with voriconazole
C :Chose voriconazole from another manufacturer
W :Drug withdrawal of voriconazole
R : Retreatment of
voriconazole
Declarations
Ethical Considerations :The
patient gave their informed consent
to participate and consent to publish , and the treatment was approved
by the institute’s committee on human research.
Competinginterests :The
authors declare that they have no conflicts of interest.
Authors’contributions :The data were collected by Zhenwen Zhu
and Yating Wang.Xihong Cao analysed all the data,and provided the
treatments with Jie Huang.The pathological analysis was done by Lijuan
Chen.Qingyu Zhang helped in imaging analysis.
Funding : No foundings.
Availability of data :The data cannot be shared openly to
protect patient’s privacy.
Reference
[1] von Lilienfeld-Toal M, Wagener J, Einsele H, Cornely OA, Kurzai
O. Invasive Fungal Infection. Dtsch Arztebl Int. 2019 Apr
19;116(16):271-278. doi: 10.3238/arztebl.2019.0271.
[2] Leeflang MM, Debets-Ossenkopp YJ, Wang J, Visser CE, Scholten
RJ, Hooft L, Bijlmer HA, Reitsma JB, Zhang M, Bossuyt PM,
Vandenbroucke-Grauls CM. Galactomannan detection for invasive
aspergillosis in immunocompromised patients. Cochrane Database Syst Rev.
2015 Dec 30;2015(12):CD007394. doi: 10.1002/14651858.CD007394.pub2.
[3] Donnelly, J. P. et al. Revision and Update of the Consensus
Definitions of Invasive Fungal Disease From the European Organization
for Research and Treatment of Cancer and the Mycoses Study Group
Education and Research Consortium. Clin Infect Dis 71, 1367-1376,
doi:10.1093/cid/ciz1008 (2020).
[4] Clemons, K. V., Schwartz, J. A. & Stevens, D. A. Experimental
central nervous system aspergillosis therapy: efficacy, drug levels and
localization, immunohistopathology, and toxicity. Antimicrob Agents
Chemother 56, 4439-4449, doi:10.1128/AAC.06015-11 (2012).