Abstract
Introduction: Cancer is the second most common cause of death
globally. It has been demonstrated that long non-coding RNAs (lncRNAs)
may play an essential role in cancer development. The lncRNA growth
arrest-special 5 (GAS5 ) is a critical tumor suppressor in many
types of human cancers. We have therefore conducted a meta-analysis to
determine the association of lncRNA GAS5 rs145204276 indel
polymorphism and cancer risk.
Methods: A comprehensive literature search in PubMed, Scopus,
and Web of Knowledge were conducted up to July 1, 2019. Eligible studies
were included in a meta-analysis. All statistical analyses were
conducted using the Metagenyo online tool.
Results: Our results showed no significant association between
the lncRNA GAS5 rs145204276 and cancer risk using all genetic
models. In subgroup analysis, the polymorphism demonstrated a
significant association with a lower risk of gastric cancer. Sensitivity
analysis confirmed the robustness of our results. No publication bias
was also identified.
Conclusions: Although the lncRNA GAS5 polymorphism is
not associated with increased cancer risk, but its polymorphism was
associated with a reduced risk of gastric cancer in subgroup analysis.
Further studies with larger sample sizes across different ethnicities
need to be performed to explore the association’s strength.
Keywords: Long non-coding RNA, GAS5 , Polymorphism,
Cancer, Meta-analysis