Quality score assessment Quality score assessment score
Representativeness of cases Representativeness of cases
Consecutive/randomly selected form case population with a clearly defined sampling frame 2
Consecutive/randomly selected form case population without a clearly defined sampling frame or with extensive 1
Not described 0
Source of controls Source of controls
Population- or Healthy-based 2
Hospital-bases 1
Not described 0
Hardy-Weinberg equilibrium in controls Hardy-Weinberg equilibrium in controls
Hardy-Weinberg equilibrium 2
Hardy-Weinberg disequilibrium 1
Not available 0
Genotyping examination Genotyping examination
Genotyping done under ”blinded” condition and repeated again 2
Genotyping done under ”blinded” condition or repeated again 1
Un-blinded done or not mentioned and unrepeated 0
Association assessment Association assessment
Assess association between genotypes and cancer with appropriate statistics and adjustment for confounders 2
Assess association between genotypes and cancer with appropriate statistics and without adjustment for confounders 1
Inappropriate statistics used 0
Total Score Total Score 10