Search strategy
A comprehensive literature search in PubMed, Scopus, and Web of Knowledge was conducted independently by the two first authors up to July 1, 2019, using the following keywords: (cancer* OR neoplas* OR carcinom* OR tumor* OR tumour* OR Malignan* OR Metasta* OR tumour*) AND (GAS5 OR ”growth arrest-specific 5 ” OR GAS-5 ORSNHG2 ) AND (mutation* OR polymorphism* OR allele* OR variant* OR SNP* OR ”single nucleotide polymorphism*”). The search was limited to English publications. Additionally, the reference lists of relevant studies were hand-searched for further articles.