CARAT
When CARAT scores at 1 week, 3 months and 1 year of treatment were compared to pre-treatment values using linear multilevel modelling, scores increased with 2.14 (95% CI 1.59 – 2.69,P <0.0001), 4.69 (4.11 – 5.26, P<0.0001), and 5.92 (5.30 – 6.55, P <0.0001), respectively. The accepted MCID is 4 points. Therefore, these results indicate that most patients improved after 3 months and 1 year of treatment (Figure 2, Table E2 ).
When separately analyzing the AR only and AR+AA subgroups, the AR+AA group had a numerical larger improvement (6.90 vs 5.38 points; P=0.06) after 1 year of treatment (see Table E2 ).