Limitations
Our study was performed using isolated coronary-perfused preparations
and the genetic defects responsible for BrS were pharmacologically
mimicked. Despite these limitations, coronary-perfused canine
ventricular models have been previously shown by us and others to be
capable of recapitulating the principal electrocardiographic arrhythmic
clinical manifestations of BrS, as well as the response to autonomic and
pharmacologic manipulation.2,25,26