3.1.2 Effect on blood glucose and insulin sensitivity
During the treatment period, the glycemic profile was evaluated through
fasting glucose (Table 2) and the insulin tolerance test (Figure 4).
Fasting blood glucose levels pre-pregnancy were increased in the FRU
group compared to the water group, whereas the FRU+VPE group showed a
decrease in glucose levels compared to the FRU group (p<0
.05). During pregnancy, blood glucose increased in the FRU group in
comparison to the water group, while FRU+VPE/Water + VPE and
FRU+VPE/Water groups showed decreased glucose levels compared to the FRU
group (p<0.05). Regarding the post-pregnancy period, the water
+ VPE group showed higher glucose levels in comparison to the water
group, whereas the interventions FRU+VPE/Water+VPE and FRU+VPE/Water
increased these levels in relation to the FRU+VPE group
(p<0.05) (Table 2).
In the pre-pregnancy period, an increase in AUC in the FRU group was
observed compared to the water group and a decrease in the FRU+VPE group
compared to the FRU group (p<0.05), indicating that at the
time of mating the females were resistant the insulin. However, in the
post-pregnancy period, there was no statistically significant difference
between the groups, since the glycemic curve of the animals was similar
(Figure 4).