3.1.3 Effect on DNA strand breaks and DNA oxidation
In the pre-pregnancy period, in both strand breaks and oxidized purine levels increased in the FRU group compared to the water group (Figure 5A; p<0.05). A decrease in oxidized DNA damage was observed in the FRU+VPE treated group compared to the FRU group (p<0.05).
The same happened in the pregnancy period, an increase in strand breaks and oxidized DNA damage was observed in the FRU group compared to the water group (Figure 5B; p<0.05). Regarding the interventions, it was observed that there was a decrease in strand breaks and oxidized DNA in the FRU+VPE, FRU+VPE/Water + VPE and FRU+VPE/Water group in comparison to the FRU group (p <0.05).
In the post-pregnancy period, we observed an increase in strand breaks and oxidized DNA damage in the FRU group compared to the water group (Figure 5C; p<0.05). In addition, a decrease in strand breaks was observed in the FRU+VPE, FRU+VPE/Water + VPE and FRU+VPE/Water groups compared to the FRU group (p<0.05).
In the liver (post-pregnancy period), an increase in DNA damage (detected as strand breaks) was observed in the FRU group in comparison to the water group and a reduction in DNA damage was observed in the FRU+VPE/Water group compared to the FRU group (Figure 6 ; p<0.05).