3.1.2 Effect on blood glucose and insulin sensitivity
During the treatment period, the glycemic profile was evaluated through fasting glucose (Table 2) and the insulin tolerance test (Figure 4).
Fasting blood glucose levels pre-pregnancy were increased in the FRU group compared to the water group, whereas the FRU+VPE group showed a decrease in glucose levels compared to the FRU group (p<0 .05). During pregnancy, blood glucose increased in the FRU group in comparison to the water group, while FRU+VPE/Water + VPE and FRU+VPE/Water groups showed decreased glucose levels compared to the FRU group (p<0.05). Regarding the post-pregnancy period, the water + VPE group showed higher glucose levels in comparison to the water group, whereas the interventions FRU+VPE/Water+VPE and FRU+VPE/Water increased these levels in relation to the FRU+VPE group (p<0.05) (Table 2).
In the pre-pregnancy period, an increase in AUC in the FRU group was observed compared to the water group and a decrease in the FRU+VPE group compared to the FRU group (p<0.05), indicating that at the time of mating the females were resistant the insulin. However, in the post-pregnancy period, there was no statistically significant difference between the groups, since the glycemic curve of the animals was similar (Figure 4).