3.2.5 Levels of DNA damage in the offspring
The alkaline comet assay was performed on peripheral tissues (blood and
liver) in the offspring (females and males) using the damage index
parameter (0-400) (figure 11).
In the evaluation of the female offspring, in the blood (figure 11), our
results demonstrated an increase in DNA damage index in the FRU group in
relation to the water group (p<0.05). In addition, was
observed a decrease in DNA damage in the FRU+ VPE, FRU+VPE/Water+VPE and
FRU+VPE/Water, in relation to the FRU group (p<0.05). No
significant differences were found in the liver.
In the male offspring was found an increase in DNA damage in the
water+VPE and FRU group in relation to the water group
(p<0.05) in the blood. A decrease in DNA damage in the
FRU+VPE, FRU+VPE/Water+VPE and FRU+VPE/Water groups compared to the FRU
group (p<0.05) was observed. Regarding the liver, an increase
in DNA damage was observed in the FRU group when compared to the water
group and a decrease in the damage index in FRU+VPE, FRU+VPE/Water+VPE
and FRU+VPE/Water in relation to the FRU group (p<0.05).