Key Messages
Children with wheeze/asthma display frequent occurrences and high levels of sensitization, but c-sIgE sensitization patterns do not clearly discriminate between non-severe and severe recurrent wheeze / asthma. Sensitization to non-specific lipid transfer protein (nsLTP) components was more frequent among SA than NSA, and was associated with lung function impairment. Cluster analysis of the results for sensitized children identified seven clusters, of which the two largest were characterized by “few sensitizations, mainly to house dust mite (HDM)”. Only one small cluster consisting of “multiple sensitizations, including to nsLTP”, was associated with severe asthma at school-age.