Total-body dynamic [11C]CFT PET Imaging
The schematic PET/CT acquisition protocol, representative maximum intensity projection (MIP) images, and the transverse views of cerebral nuclei and GI organs acquired at different time points were shown inFigure 1 . In the total-body dynamic [11C]CFT PET imaging, the tracer uptake in the central and peripheral regions throughout the entire body were clearly visualized, even in deep brain areas like the substantial nigra, which was usually limited by resolution with conventional PET scanner. Based on the visual assessment, the uptake of [11C]CFT in the nigrostriatal nuclei of HC is intact and persistent, while PD patients displayed asymmetric DAT depletion in the corresponding areas. No distinct difference was observed from the visual assessment of GI organ regions between the HC and PD groups.