Figure Legends
FIGURE 1 (A)Total-body dynamic [11C]CFT PET/CT scanning
protocol (75 min, 97 frames). (B-D) Selected view from
[11C]CFT dynamic reconstructed images of a
53-year-old healthy volunteer (HC) and a 57-year-old Parkinson’s disease
patient (PD). (B) Total-body maximum intensity projection
(MIP). (C) Transverse views of cerebral nuclei both in the
striatal and substantial nigra plane. The [11C]CFT
uptake in HC developed earlier and increased over time, while the
nigrostriatal dopamine depletion was finally found in PD with a
caudal-rostral gradient tendency especially in the left side.
(D) Transverse views of the upper abdomen. Abbreviation: HC,
healthy controls; PD, Parkinson’s disease patients.
FIGURE 2 Comparison of averaged SUVmean curves
in HC and PD group at the (A) descending aorta, (B)occipital lobe, selected (C) cerebral nuclei regions and
(D) GI organs. Data are represented by mean ± standard error
mean (SEM). Separation time between the averaged SUVmeancurves of HC and PD groups were marked for the cerebral nuclei regions.
FIGURE 3 (A) Schematic representation of the
simplified reference tissue model (SRTM2). (B) Total-body
maximum intensity projection (MIP) generated from the voxel-based SRTM2
modeling (left column), and representative striatal and substantial
nigra planes of the R1 and DVR parametric images in HC
and PD representatives (right column). (C) Correlation between
the quantitative and semi-quantitative measurements. The
semi-quantitative estimation for early perfusion
(SUVREP) (left) and dopamine transporter density
(SUVRLP) (right) were both significantly correlated to
the quantitative parameters (R1 and DVR, respectively).(D) Significant differences between the HC and PD groups in
SUVREP of stomach (left) and both DVR (middle) and
SUVRLP (right) of putamen.
FIGURE 4 Correlative assessment of the (A)R1 and (B) SUVREP of stomach
and substantial nigra, and the (C) DVR and (D)SUVRLP of pancreas and putamen in the HC and PD groups.
Abbreviation: SN, substantia nigra
FIGURE 5 Correlation based on the quantitative measurements of
(A) R1 and (B) DVR, and
semi-quantitative estimation of (C) SUVREP and(D) SUVRLP between the cerebral nuclei and GI
organs in healthy controls (HC) and Parkinson’s disease patients (PD).
Upper triangle gives the graphical demonstration of the correlation,
where the orientations of the ellipses represent the signs of the
correlation coefficient (upper-left to lower-right, negative; lower-left
to upper-right, positive), and colors and width represent the magnitude
of the coefficients. The asterisks represent the significance (*,P <0.05; **, P <0.01; ***,P <0.001). The lower triangle displays the correlation
coefficient r . Abbreviation: SN, substantia nigra.