Total-body dynamic [11C]CFT PET Imaging
The schematic PET/CT acquisition protocol, representative maximum
intensity projection (MIP) images, and the transverse views of cerebral
nuclei and GI organs acquired at different time points were shown inFigure 1 . In the total-body dynamic
[11C]CFT PET imaging, the tracer uptake in the
central and peripheral regions throughout the entire body were clearly
visualized, even in deep brain areas like the substantial nigra, which
was usually limited by resolution with conventional PET scanner. Based
on the visual assessment, the uptake of [11C]CFT
in the nigrostriatal nuclei of HC is intact and persistent, while PD
patients displayed asymmetric DAT depletion in the corresponding areas.
No distinct difference was observed from the visual assessment of GI
organ regions between the HC and PD groups.