Kinetic analysis features
The total-body [11C]CFT PET parametric images based on the SRTM2 model were generated. The schematic formula of SRTM2 and representative R1 and DVR parametric images of HC and PD participants were illustrated in Figure 3A andB . The statistically significant correlation was observed between the parameters of quantitative and semi-quantitative analysis, including R1 and SUVREP (r =0.776,P <0.001), DVR and SUVRLP(r =0.921,P <0.001), suggesting an agreement between the two analysis approaches (Figure 3C ). In the comparison of the quantitative parameters between HC and PD groups, statistical significances were found between the HC and PD groups in terms of SUVREP of stomach (P <0.01) and both DVR and SUVRLPof putamen (P <0.05) (Figure 3D ).
We further demonstrated that the R1 and DVR estimated from the SRTM2 using the occipital lobe as the reference was highly correlated with the K1 and VT generated from the 1T2K models (r = 0.84 and 0.83, respectively, bothP <0.0001) (Supplemental Figure 1A andB ), suggesting the accurate tracer quantification without arterial sampling.