Kinetic Analysis with Semi-Quantification Approach
SUVR, calculated as the ratio between the SUV of the targeted area and
occipital lobe reference region, served as an approximation of early
blood perfusion and DAT expression level with an advantage of shorter
scan acquisition time for clinical setting. The whole dynamic scanning
period of [11C]CFT was subdivided into the early
phase (SUVREP for 1-3 min) and late phase
(SUVRLP for 60-75 min), where SUVREP was
used to estimate R1 and SUVRLP can be
used as an approximation of the tracer specific binding to DAT
resembling DVR 21.