Kinetic Analysis with Semi-Quantification Approach
SUVR, calculated as the ratio between the SUV of the targeted area and occipital lobe reference region, served as an approximation of early blood perfusion and DAT expression level with an advantage of shorter scan acquisition time for clinical setting. The whole dynamic scanning period of [11C]CFT was subdivided into the early phase (SUVREP for 1-3 min) and late phase (SUVRLP for 60-75 min), where SUVREP was used to estimate R1 and SUVRLP can be used as an approximation of the tracer specific binding to DAT resembling DVR 21.