Figure Legends
FIGURE 1 (A)Total-body dynamic [11C]CFT PET/CT scanning protocol (75 min, 97 frames). (B-D) Selected view from [11C]CFT dynamic reconstructed images of a 53-year-old healthy volunteer (HC) and a 57-year-old Parkinson’s disease patient (PD). (B) Total-body maximum intensity projection (MIP). (C) Transverse views of cerebral nuclei both in the striatal and substantial nigra plane. The [11C]CFT uptake in HC developed earlier and increased over time, while the nigrostriatal dopamine depletion was finally found in PD with a caudal-rostral gradient tendency especially in the left side. (D) Transverse views of the upper abdomen. Abbreviation: HC, healthy controls; PD, Parkinson’s disease patients.
FIGURE 2 Comparison of averaged SUVmean curves in HC and PD group at the (A) descending aorta, (B)occipital lobe, selected (C) cerebral nuclei regions and (D) GI organs. Data are represented by mean ± standard error mean (SEM). Separation time between the averaged SUVmeancurves of HC and PD groups were marked for the cerebral nuclei regions.
FIGURE 3 (A) Schematic representation of the simplified reference tissue model (SRTM2). (B) Total-body maximum intensity projection (MIP) generated from the voxel-based SRTM2 modeling (left column), and representative striatal and substantial nigra planes of the R1 and DVR parametric images in HC and PD representatives (right column). (C) Correlation between the quantitative and semi-quantitative measurements. The semi-quantitative estimation for early perfusion (SUVREP) (left) and dopamine transporter density (SUVRLP) (right) were both significantly correlated to the quantitative parameters (R1 and DVR, respectively).(D) Significant differences between the HC and PD groups in SUVREP of stomach (left) and both DVR (middle) and SUVRLP (right) of putamen.
FIGURE 4 Correlative assessment of the (A)R1 and (B) SUVREP of stomach and substantial nigra, and the (C) DVR and (D)SUVRLP of pancreas and putamen in the HC and PD groups. Abbreviation: SN, substantia nigra
FIGURE 5 Correlation based on the quantitative measurements of (A) R1 and (B) DVR, and semi-quantitative estimation of (C) SUVREP and(D) SUVRLP between the cerebral nuclei and GI organs in healthy controls (HC) and Parkinson’s disease patients (PD). Upper triangle gives the graphical demonstration of the correlation, where the orientations of the ellipses represent the signs of the correlation coefficient (upper-left to lower-right, negative; lower-left to upper-right, positive), and colors and width represent the magnitude of the coefficients. The asterisks represent the significance (*,P <0.05; **, P <0.01; ***,P <0.001). The lower triangle displays the correlation coefficient r . Abbreviation: SN, substantia nigra.