Author Contributions
Cock van Oosterhout and Samuel Speak conceived the study; Samuel Speak
and Chiara Bortoluzzi developed the CADD analysis methods; Samuel Speak
developed the LoadLift Snakemake and analysed the genomic data; Thomas
Birley and Hernán Morales conducted the SLIM simulations; Chiara
Bortoluzzi, Matthew Clark, Lawrence Percival-Alwyn, Hernán Morales and
Cock van Oosterhout supervised the study; Matthew Clark and Lawrence
Percival-Alwyn contributed to DNA sequencing; Samuel Speak, Hernán
Morales and Cock van Oosterhout wrote the paper; all authors contributed
to the manuscript and approved.