Day -1 Day 7 Day 14 Day 28 Day 42
Midazolam (po) Cmax (ng mL-1) n 20 20 20 20 20
Estimated ratio after inverse logarithmic conversion 1.65 1.86 1.08 1.09
90% CI of the ratio 1.45 – 1.87 1.64 – 2.11 0.95 – 1.22 0.96 – 1.23
p-value <.0001 <.0001 0.3214 0.2820
AUC0-t (ng h mL-1) n 20 20 20 20 20
Estimated ratio after inverse logarithmic conversion 2.69 3.07 1.12 1.08
90% CI of the ratio 2.47 – 2.94 2.81 – 3.35 1.02 – 1.22 0.98 – 1.17
p-value <.0001 <.0001 0.0400 0.1778
Prednisolone (po) Cmax (ng mL-1) n 20 20 20 20 19
Estimated ratio after inverse logarithmic conversion 0.87 0.89 0.96 0.87
90% CI of the ratio 0.82 – 0.92 0.84 – 0.95 0.91- 1.02 0.82 – 0.92
p-value 0.0001 0.0017 0.2643 0.0002
AUC0-t (ng h mL-1) n 20 20 20 20 19
Estimated ratio after inverse logarithmic conversion 1.04 1.11 1.00 0.98
90% CI of the ratio 1.01 – 1.08 1.08 – 1.15 0.97 – 1.04 0.94 – 1.01
p-value 0.0471 <.0001 0.9269 0.2537
Atorvastatin (po) Cmax (ng mL-1) n 20 19 19 19 19
Estimated ratio after inverse logarithmic conversion 1.00 1.24 1.06 1.02
90% CI of the ratio 0.81 – 1.22 1.01 – 1.52 0.87 – 1.30 0.83 – 1.25
p-value 0.9651 0.0853 0.6236 0.8932
AUC0-t (ng h mL-1) n 20 19 19 19 19
Estimated ratio after inverse logarithmic conversion 1.75 2.10 1.13 1.15
90% CI of the ratio 1.64 – 1.87 1.97 – 2.24 1.06 – 1.20 1.08 – 1.23
p-value <.0001 <.0001 0.0033 0.0006
Midazolam (iv) AUC0-t (ng h mL-1) n 20 19 19 19 19
Estimated ratio after inverse logarithmic conversion 1.40 1.53 1.16 1.11
90% CI of the ratio 1.30 – 1.50 1.43 – 1.64 1.08 – 1.24 1.03 – 1.19
p-value <.0001 <.0001 0.0009 0.0207