What this study adds
In humans, carotegrast methyl was a moderate CYP3A4 inhibitor, and
after 14 days treatment with carotegrast methyl, the combination with
CYP3A4 substrates including midazolam and atorvastatin increased their
exposure.
The inhibitory effect of
carotegrast methyl on CYP3A4 had almost disappeared by 14 days after
the end of administration.