|
|
|
|
S_AJM300 |
CO_RIFAMPICIN |
Carotegrast methyl |
Cmax (ng mL-1) |
Cmax (ng mL-1) |
Mean ± SD |
1047.8 ±
846.8 |
1973.8 ± 1151.7 |
|
|
|
Geometric Mean |
803.4 |
1670.4 |
|
|
|
95% CI |
572.7, 1126.9 |
1252.7, 2227.3 |
|
AUC0-t (ng h mL-1) |
AUC0-t (ng h mL-1) |
Mean ± SD |
2583.0 ± 1522.9 |
5087.8 ± 2626.0 |
|
|
|
Geometric Mean |
2199.1 |
4450.1 |
|
|
|
95% CI |
1674.1, 2888.7 |
3432.7, 5769.1 |
|
Tmax (h) |
Tmax (h) |
Median (min,
max) |
1.0 (0.5, 4.0) |
2.0 (0.5, 4.0) |
|
t1/2 (h) |
t1/2 (h) |
Mean ± SD |
3.1
± 1.2 |
4.0 ± 1.5 |
|
|
|
Geometric Mean |
2.8 |
3.7 |
|
|
|
95% CI |
2.2, 3.5 |
3.1, 4.4 |
|
MRT0-t (h) |
MRT0-t (h) |
Mean ± SD |
2.3 ± 0.6 |
2.4 ± 0.6 |
|
|
|
Geometric Mean |
2.2 |
2.3 |
|
|
|
95% CI |
1.9, 2.5 |
2.1, 2.6 |
Carotegrast |
Cmax (ng mL-1) |
Cmax (ng mL-1) |
Mean ± SD |
2620.1 ±
1843.0 |
11724.5 ± 6097.6 |
|
|
|
Geometric Mean |
2170.1 |
10380.6 |
|
|
|
95% CI |
1629.8, 2889.4 |
8133.2, 13249.0 |
|
AUC0-t (ng h mL-1) |
AUC0-t (ng h mL-1) |
Mean ± SD |
9849.9 ± 4580.6 |
55046.0 ± 23427.8 |
|
|
|
Geometric Mean |
9051.3 |
50548.0 |
|
|
|
95% CI |
7477.7, 10956.1 |
41286.2, 61887.5 |
|
Tmax (h) |
Tmax (h) |
Median (min,
max) |
2.0 (1.0, 4.0) |
4.0 (2.0, 4.0) |
|
t1/2 (h) |
t1/2 (h) |
Mean ± SD |
8.8
± 11.2 |
5.3 ± 2.8 |
|
|
|
Geometric Mean |
6.6 |
4.9 |
|
|
|
95% CI |
4.9, 8.8 |
4.2, 5.8 |
|
MRT0-t (h) |
MRT0-t (h) |
Mean ± SD |
4.8 ± 1.2 |
5.3 ± 0.8 |
|
|
|
Geometric Mean |
4.6 |
5.2 |
|
|
|
95% CI |
4.1, 5.2 |
4.9, 5.6 |
M-I |
Cmax (ng mL-1) |
Cmax (ng mL-1) |
Mean ± SD |
40.6 ±
30.3 |
50.7 ± 19.7 |
|
|
|
Geometric Mean |
33.0 |
46.9 |
|
|
|
95% CI |
24.5, 44.5 |
38.6, 57.0 |
|
AUC0-t (ng h mL-1) |
AUC0-t (ng h mL-1) |
Mean ± SD |
85.6
± 48.7 |
124.2 ± 40.3 |
|
|
|
Geometric Mean |
73.7 |
116.5 |
|
|
|
95% CI |
56.4, 96.3 |
97.0, 139.9 |
|
Tmax (h) |
Tmax (h) |
Median (min,
max) |
1.0 (0.5, 2.0) |
1.0 (0.5, 4.0) |
|
t1/2 (h) |
t1/2 (h) |
Mean ± SD |
1.1
± 0.6 |
1.0 ± 0.7 |
|
|
|
Geometric Mean |
1.0 |
0.9 |
|
|
|
95% CI |
0.8, 1.3 |
0.7, 1.1 |
|
MRT0-t (h) |
MRT0-t (h) |
Mean ± SD |
1.8 ± 0.6 |
1.9 ± 0.7 |
|
|
|
Geometric Mean |
1.7 |
1.8 |
|
|
|
95% CI |
1.4, 2.0 |
1.6, 2.1 |
M-II |
Cmax (ng mL-1) |
Cmax (ng mL-1) |
Mean ± SD |
199.9 ±
146.4 |
641.5 ± 218.8 |
|
|
|
Geometric Mean |
168.3 |
600.1 |
|
|
|
95% CI |
130.3, 217.4 |
498.3, 722.7 |
|
AUC0-t (ng h mL-1) |
AUC0-t (ng h mL-1) |
Mean ± SD |
789.5
± 367.7 |
4617.6 ± 1387.5 |
|
|
|
Geometric Mean |
723.7 |
4378.0 |
|
|
|
95% CI |
596.6, 877.8 |
3704.5, 5174.0 |
|
Tmax (h) |
Tmax (h) |
Median (min,
max) |
2.0 (1.0, 4.0) |
4.0 (2.0, 6.0) |
|
t1/2 (h) |
t1/2 (h) |
Mean ± SD |
5.5
± 1.8 |
3.7 ± 0.6 |
|
|
|
Geometric Mean |
5.3 |
3.7 |
|
|
|
95% CI |
4.6, 6.1 |
3.4, 4.0 |
|
MRT0-t (h) |
MRT0-t (h) |
Mean ± SD |
4.6 ± 0.9 |
6.8 ± 0.8 |
|
|
|
Geometric Mean |
4.5 |
6.7 |
|
|
|
95% CI |
4.1, 5.0 |
6.4, 7.1 |
Carotegrast-gluc |
Carotegrast-gluc |
Cmax (ng mL-1) |
Mean ± SD |
803.7 ±
430.2 |
622.2 ± 243.2 |
|
|
|
Geometric Mean |
729.2 |
577.5 |
|
|
|
95% CI |
597.0, 890.5 |
477.9, 697.8 |
|
|
AUC0-t (ng h mL-1) |
Mean ± SD |
2998.4 ± 1081.2 |
3414.8 ± 1085.3 |
|
|
|
Geometric Mean |
2855.6 |
3243.2 |
|
|
|
95% CI |
2473.8, 3296.3 |
2766.5, 3802.1 |
|
|
Tmax (h) |
Median (min, max) |
2.0 (1.0, 4.0) |
2.0
(1.0, 4.0) |
|
|
t1/2 (h) |
Mean ± SD |
6.5 ± 2.9 |
6.0 ±
1.6 |
|
|
|
Geometric Mean |
6.0 |
5.8 |
|
|
|
95% CI |
4.8, 7.3 |
5.2, 6.6 |
|
|
MRT0-t (h) |
Mean ± SD |
4.4 ± 1.0 |
5.8 ±
0.8 |
|
|
|
Geometric Mean |
4.3 |
5.7 |
|
|
|
95% CI |
3.8, 4.7 |
5.4, 6.1 |