FIGURE LEGENDS
Figure 1 Metabolic map of carotegrast methyl in humans
The metabolic map was generated based on a human mass balance study in
healthy adults.
Figure 2 Study design
Figure 3 Study flow
Figure 4 Time course of mean + standard deviation of plasma
concentration of (A) carotegrast methyl (B) carotegrast, (C) M-I, (D)
M-II, and (E) carotegrast glucuronate (carotegrast gluc) after oral
carotegrast methyl 960 mg administration in the presence (□) and absence
(●) of oral rifampicin 600 mg.