S_AJM300 CO_RIFAMPICIN
Carotegrast methyl Cmax (ng mL-1) Cmax (ng mL-1) Mean ± SD 1047.8 ± 846.8 1973.8 ± 1151.7
Geometric Mean 803.4 1670.4
95% CI 572.7, 1126.9 1252.7, 2227.3
AUC0-t (ng h mL-1) AUC0-t (ng h mL-1) Mean ± SD 2583.0 ± 1522.9 5087.8 ± 2626.0
Geometric Mean 2199.1 4450.1
95% CI 1674.1, 2888.7 3432.7, 5769.1
Tmax (h) Tmax (h) Median (min, max) 1.0 (0.5, 4.0) 2.0 (0.5, 4.0)
t1/2 (h) t1/2 (h) Mean ± SD 3.1 ± 1.2 4.0 ± 1.5
Geometric Mean 2.8 3.7
95% CI 2.2, 3.5 3.1, 4.4
MRT0-t (h) MRT0-t (h) Mean ± SD 2.3 ± 0.6 2.4 ± 0.6
Geometric Mean 2.2 2.3
95% CI 1.9, 2.5 2.1, 2.6
Carotegrast Cmax (ng mL-1) Cmax (ng mL-1) Mean ± SD 2620.1 ± 1843.0 11724.5 ± 6097.6
Geometric Mean 2170.1 10380.6
95% CI 1629.8, 2889.4 8133.2, 13249.0
AUC0-t (ng h mL-1) AUC0-t (ng h mL-1) Mean ± SD 9849.9 ± 4580.6 55046.0 ± 23427.8
Geometric Mean 9051.3 50548.0
95% CI 7477.7, 10956.1 41286.2, 61887.5
Tmax (h) Tmax (h) Median (min, max) 2.0 (1.0, 4.0) 4.0 (2.0, 4.0)
t1/2 (h) t1/2 (h) Mean ± SD 8.8 ± 11.2 5.3 ± 2.8
Geometric Mean 6.6 4.9
95% CI 4.9, 8.8 4.2, 5.8
MRT0-t (h) MRT0-t (h) Mean ± SD 4.8 ± 1.2 5.3 ± 0.8
Geometric Mean 4.6 5.2
95% CI 4.1, 5.2 4.9, 5.6
M-I Cmax (ng mL-1) Cmax (ng mL-1) Mean ± SD 40.6 ± 30.3 50.7 ± 19.7
Geometric Mean 33.0 46.9
95% CI 24.5, 44.5 38.6, 57.0
AUC0-t (ng h mL-1) AUC0-t (ng h mL-1) Mean ± SD 85.6 ± 48.7 124.2 ± 40.3
Geometric Mean 73.7 116.5
95% CI 56.4, 96.3 97.0, 139.9
Tmax (h) Tmax (h) Median (min, max) 1.0 (0.5, 2.0) 1.0 (0.5, 4.0)
t1/2 (h) t1/2 (h) Mean ± SD 1.1 ± 0.6 1.0 ± 0.7
Geometric Mean 1.0 0.9
95% CI 0.8, 1.3 0.7, 1.1
MRT0-t (h) MRT0-t (h) Mean ± SD 1.8 ± 0.6 1.9 ± 0.7
Geometric Mean 1.7 1.8
95% CI 1.4, 2.0 1.6, 2.1
M-II Cmax (ng mL-1) Cmax (ng mL-1) Mean ± SD 199.9 ± 146.4 641.5 ± 218.8
Geometric Mean 168.3 600.1
95% CI 130.3, 217.4 498.3, 722.7
AUC0-t (ng h mL-1) AUC0-t (ng h mL-1) Mean ± SD 789.5 ± 367.7 4617.6 ± 1387.5
Geometric Mean 723.7 4378.0
95% CI 596.6, 877.8 3704.5, 5174.0
Tmax (h) Tmax (h) Median (min, max) 2.0 (1.0, 4.0) 4.0 (2.0, 6.0)
t1/2 (h) t1/2 (h) Mean ± SD 5.5 ± 1.8 3.7 ± 0.6
Geometric Mean 5.3 3.7
95% CI 4.6, 6.1 3.4, 4.0
MRT0-t (h) MRT0-t (h) Mean ± SD 4.6 ± 0.9 6.8 ± 0.8
Geometric Mean 4.5 6.7
95% CI 4.1, 5.0 6.4, 7.1
Carotegrast-gluc Carotegrast-gluc Cmax (ng mL-1) Mean ± SD 803.7 ± 430.2 622.2 ± 243.2
Geometric Mean 729.2 577.5
95% CI 597.0, 890.5 477.9, 697.8
AUC0-t (ng h mL-1) Mean ± SD 2998.4 ± 1081.2 3414.8 ± 1085.3
Geometric Mean 2855.6 3243.2
95% CI 2473.8, 3296.3 2766.5, 3802.1
Tmax (h) Median (min, max) 2.0 (1.0, 4.0) 2.0 (1.0, 4.0)
t1/2 (h) Mean ± SD 6.5 ± 2.9 6.0 ± 1.6
Geometric Mean 6.0 5.8
95% CI 4.8, 7.3 5.2, 6.6
MRT0-t (h) Mean ± SD 4.4 ± 1.0 5.8 ± 0.8
Geometric Mean 4.3 5.7
95% CI 3.8, 4.7 5.4, 6.1