6.1.5 Treatment setting
There is a large variation across the existing studies for psychedelics for OUD studies in regard to treatment settings. For example, the early LSD studies were mostly carried out in residential settings, the study investigating ayahuasca was completed in a retreat setting, and many of the trials with ibogaine or noribogaine were carried out in various medical treatment centers. Pain studies have traditionally occurred in two settings: (1) human laboratory investigations and (2) real-word, ambulatory and emergency room studies. Treatment setting determination may also be influenced by which phase of treatment is being targeted (i.e., acute withdrawal) or by other safety concerns that may require continuous medical monitoring. Treatment setting is overall an important consideration for research design but also for real-world implementation if such psychedelic treatments receive regulatory approval.