Affiliations
1Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
2Department of Cell Biology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
3 National Heart and Lung Institute Faculty of Medicine (NHLI), Imperial College
22 London, Hammersmith campus, W12 0NN, London, UK
4 Medical Research Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
5 Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
6 Clinical Research Center for Pediatric Liver Transplantation of Capital Medical University, Beijing 100050, China.
7 Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Peking University Hepatology Institute, Peking University People’s Hospital, Beijing, 100044, China.
# These authors contributed equally to this study
* Corresponding author:
Xiangmei Chen:
Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
Tel: +86-10-82802807; Fax: +86-10-82805136;
E-mail:xm_chen6176@bjmu.edu.cn
Fengmin Lu:
Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Peking University Hepatology Institute, Peking University People’s Hospital, Beijing, 100044, China.
Tel: 86-10-8280-5136; Fax: 86-10-8280-5136
E-mail: lu.fengmin@hsc.pku.edu.cn
Guiwen Guan
Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
Tel: 86-188-1017-2170
E-mail: guanguiwen@bjmu.edu.cn
Keywords: Hepatitis B virus; Viral integration; PLC/PRF/5; Multi-omics; Cripsr-cas9; RNA Interference.