Type 2 Inflammation of the Lower Airways: impacts on the
Laryngopharynx
Asthma affect up to one fifth of the general population[32 ],
characterized by airway hyper responsiveness and reversible pulmonary
function impairments on spirometry[33 ]. Classical lower
airway symptoms including cough, wheezing, and dyspnoea. Non-asthma
variants also characterised by lower airway eosinophilia have been
identified, including cough-variant asthma (CVA) and non-asthma
eosinophilic bronchitis (NAEB), also termed atopic cough (AC). In CVA,
patients present with cough but no airway limiting symptoms, and
reversible pulmonary function impairments[33 ]. In NAEB/AC,
chronic cough with sputum and bronchial eosinophilia [34 ]
occurs without the pulmonary function impairments seen in asthma and
CVA. In these disorders, cough is a primary symptom related to lower
airway type 2 inflammation, and thus is excluded from our analysis inTable 1 . The prevalence of non-cough UCTS in lower airway were
infrequently reported, and available data predominantly concerns studies
of asthma patients, with most attention given to voice related
complaints. In general, data presented in Table 1 re-iterates a
view that non-cough symptoms are more prevalent in populations with
lower airway allergy.