Primary Symptoms
IgE mediated Type 2 inflammation of the Laryngopharynx Though AL is not yet widely accepted as a form or phenotype of airway allergy, the capacity for the laryngopharynx to mount a type 2 IgE mediated inflammatory reaction in the presence of inhaled allergens appears plausible, bolstered by observed eosinophilic inflammatory reactions in several small human and animal provocation studies[14, 16, 23]. The laryngopharynx, in keeping with its continuity with nasal and bronchial airways, is populated with mast cells and goblet cells[19, 20,23], and the laryngeal inlet by virtue of its function is routinely exposed to deposition of inhaled particulates and antigens, exacerbated in patients with nasal allergy and resulting nasal obstruction. Further investigation is required to determine the significance of potential primary mucosal-allergen interactions in this setting, given implications both for therapy and for united airway interactions.