Table 1. Reported association between eosinophilic airway
disease variants and chronic aerodigestive symptoms |
Table 1.
Reported association between eosinophilic airway disease variants and
chronic aerodigestive symptoms |
Table 1. Reported association
between eosinophilic airway disease variants and chronic aerodigestive
symptoms |
Table 1. Reported association between eosinophilic
airway disease variants and chronic aerodigestive symptoms |
|
Chronic cough |
Vocal symptoms |
Sensory
symptoms (globus, tickle, catarrh sensation, urge to clear throat) |
Nasal allergy
|
Numerous studies identify chronic cough as a primary symptom of
AR/ACRS[57] [24] [58] [38]
[59] [60] [29]
|
AR patients show subjective and objective derangements of voice quality.
VHI scores show increase, while VS parameters do not change with the
severity of AR.[61]
Mean VHI score (p=0.001) were significantly higher in the allergic
rhinitis group than in controls.[62]
Patients with either AR or NAR had higher odds of dysphonia (odds ratio,
4.22; 95% confidence interval, 1.03 to 17.32) when confounding
variables such as asthma, inhaled steroid use, and gastroesophageal
reflux are controlled for,.[47]
In a cohort with non-structural dysphonia, AR was detected at three
times the rate of LPR.[35]
[2]Both subjective
and objective voice parameters were impaired in AR patients during
pollen season, and in both measures this improved to near control levels
after treatment [63]
Results showed that in singers with AR both nasal (TNS of 4.0 ± 2.4 vs.
0.0 ± 0.0, p < 0.05) and laryngeal complaints (TLS of 1.4 ±
1.1 vs. 0.0 ± 0.2, p < 0.05) were induced at 3 min after the
provocation. The induced laryngeal complaints were the feeling of
laryngeal irritation, secretions and globus. [64]
|
Results showed that in singers with AR both nasal (TNS of 4.0 ± 2.4 vs.
0.0 ± 0.0, p < 0.05) and laryngeal complaints (TLS of 1.4 ±
1.1 vs. 0.0 ± 0.2, p < 0.05) were induced at 3 min after the
provocation. The induced laryngeal complaints were the feeling of
laryngeal irritation, secretions and globus. [64]
Dysphonia, frequent throat cleaning, and a globus sensation are common
presentations of LPR and allergic rhinitis/laryngitis. and allergic
rhinitis/laryngitis. [17]
Subjective sensory symptoms of itch, irritation, mucus sticking in the
throat are reported in 33-82% of patients with allergic
rhinitis[36]
In patients with birch pollinosis AR, 55% reported laryngeal symptoms
such as cough, itch and globus. [65]
|
Lower airway allergy
|
##
|
In asthmatic patients, maximum phonation time, frequency, and amplitude
perturbation parameters were impaired, but the vital capacity and the
duration of illness did not correlate with these
findings.[66]
[2]Values for F0, jitter, and
shimmer were very similar between asthmatics and non-asthmatics, but
there were statistically significant differences in values for
harshness, hoarseness, NNE, S/Z ratio (all p 0.01), and breathiness (p =
0.015). Findings suggest that lower airway diseases such as asthma can
impair phonation. [67].
Dysphonia is significantly more prevalent in patients with asthma
compared to controls.[68]
[2]Compared with
non-asthma participants, asthma patients who had not taken asthma
medication recently showed a higher AOR (1.62; 95% CI = 1.0–2.42) for
dysphonia, and asthma patients who had taken asthma medication recently
showed the highest adjusted odds ratio for dysphonia (AOR = 1.97; 95%
confidence interval, CI = 1.28–3.02, P = 0.001). [69]
Vocal morbidity is common in patients with asthma, and should not be
immediately attributed to steroid-related
candidiasis.[5]
|
Laryngeal hypersensitivity and impaired voice measures were common in
severe asthma.[70]
Laryngeal sensory symptoms in patients with classical asthma (CA) or
cough predominant asthma (CPA) were reported as follows
CA: Itchy throat 44% Abnormal sensations 30% recurrent throat clearing
27% sensation of mucus in the throat 30.2%
CPA: Itchy throat 56.5%, abnormal sensations in the throat 30%,
recurrent throat clearing 32.5%, sensation of mucus in the throat
31.5% [33]
Both laryngeal allergy and AC are associated with persistent dry cough,
globus, atopic factors, the absence of bronchial hyperresponsiveness,
and are responsive to antihistamines. [71]
|
## Cough related data was omitted in the case of Lower Airway
Allergy
VHI: Vocal handicap index VS: Vocal stroboscopy
|
## Cough related data was omitted in the case of Lower Airway
Allergy
VHI: Vocal handicap index VS: Vocal stroboscopy
|
## Cough related data was omitted in the case of Lower Airway
Allergy
VHI: Vocal handicap index VS: Vocal stroboscopy
|
## Cough related data was omitted in the case of Lower Airway
Allergy
VHI: Vocal handicap index VS: Vocal stroboscopy
|