ChILD Associated with Autoimmune and Autoinflammatory Disorders
As with IEIs, pulmonary complications including ILD are among the most severe and life-threatening complications of acquired autoimmune and autoinflammatory disorders. This review will focus on disorders with the most significant pulmonary involvement, including systemic sclerosis (SSc), juvenile dermatomyositis (JDM), systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD), Sjögren’s syndrome, sarcoidosis, anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV), and systemic juvenile idiopathic arthritis (sJIA). Pulmonary manifestations of these disorders and representative CT images are summarized in figures 2 and 3 respectively. Through a collaborative approach, rheumatologists and pulmonologists can work together to make earlier diagnosis and improve clinical outcomes for patients with these disorders.