Details of Ethics Approval:
In this study we used data from the Screening for Pregnancy Endpoints (SCOPE) study, with trial registration ACTRN 12607000551493 (approved 26 October 2007). Ethical approval was also obtained from local ethics committees of participating countries (New Zealand: Northern X Regional Ethics Committee [ref AKX/02/00/364, approved 23 April 203]; Australia: Central Northern Adelaide Health Service, Ethics of Human Research Committee [ref 2005082, approved 2 September 2005]; United Kingdom: South East Multi-centre Research Ethics Committee & Central Manchester Research Ethics Committee [ref 06/MRE01/98, approved 19 January 2007]; Ireland: Clinical Research Ethics Committee of the Cork Teaching Hospitals [ref 06/MRE01/98, approved 19 January 2007]).