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\begin{document}

\title{Clinical Analysis of Air-Leak Syndrome Following Allogeneic
Hematopoietic Stem Cell Transplantation in Pediatric Patients}



\author[1]{Man Chen}%
\author[2]{Wei Zhao}%
\affil[1]{Shanghai Lu Daopei Hospital}%
\affil[2]{Beijing Lu Daopei Hospital}%


\vspace{-1em}



  
  \date{May 24, 2024}


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\begin{abstract}
Air-leak syndrome (ALS) is an independent poor prognosis factor among
adult patients who have received hematopoietic stem cell transplantation
(HSCT), which 5-year overall survival (OS) is less than 30\%. However,
the clinical features of ALS among post-transplant pediatric patients
have rarely been explored.We retrospectively reviewed 2,206 pediatric
patients who received an allo-HSCT between January 2013 and December
2019 at the Hebei Yanda Lu Daopei Hospital and analyzed the role of ALS
in their prognosis following HSCT.We divided ALS into two categories: 15
cases of bronchiolitis obliterans syndrome (BOS) and 13 cases of
idiopathic pneumonia syndrome (IPS).Following treatment of the ALS, 18
patients survived (18/28, 64.3\%) and 10 patients died of respiratory
failure or infection (10/28, 35.7\%). The OS of ALS in our hospital is
significantly higher than that cited in previous reports which may be
related to early diagnosis and timely FAM treatment.%
\end{abstract}%



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\verb`Clinical Analysis of Air-Leak Syndrome Following Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Patients 3.doc`  available at \url{https://authorea.com/users/675847/articles/673664-clinical-analysis-of-air-leak-syndrome-following-allogeneic-hematopoietic-stem-cell-transplantation-in-pediatric-patients}\selectlanguage{english}
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\textbf{Hosted file}

\verb`Table 2.docx`  available at \url{https://authorea.com/users/675847/articles/673664-clinical-analysis-of-air-leak-syndrome-following-allogeneic-hematopoietic-stem-cell-transplantation-in-pediatric-patients}

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