EGCG |
Epigallocatechin gallate |
CB-17 rodents with severe
combined immunodeficiency |
100 mg/kg of EGCG dissolved into 100 L of
water is administered orally every two days. |
Reduce tumor
proliferation; reduce miR-25 expression; reduce Ki-67; and enhance
pro-apoptotic PARP expression |
(50) |
Artemisinin
(Artesunate)
|
Artemisia annua
|
Xenograft model of 4T1 cells in female BALB/c mice
|
Every day intraperitoneal injection of 100 mg/kg artemisinin dissolved
in 0.2% DMSO for twenty days
|
Reduced splenic and tumor Treg and MDSC growth; enhanced percentages of
CD4 + IFN- + T cells; elevated FN- and TNF-
|
|
Ginseng |
Ginseng |
Xenograft model of MCF-7 cells in female
BALB/c athymic nude mice |
Ginseng extract (50 or 100 mg/kg) was given
intravenously once a day for four weeks |
Increase Bax, activated
caspase-3, and activated PARP; reduced Bcl-2; reduced tumor weight |
(51) |
Resveratrol |
skin of grapes, blueberries, raspberries,
mulberries, and peanuts |
Xenograft model of MDA-MB-231 cells in female
athymic mice |
resveratrol (ethanolic solution) 25 mg/kg/day
intraperitoneally for three weeks |
reduce tumor size, boost apoptotic
index, and stop angiogenesis |
(52) |
Curcumin |
Turmeric or Curcuma longa |
Female athymic nude mice
with BT-474 xenograft mod-el overexpressing HER-2 |
Curcumin was
administered intraperitoneally twice weekly for a period of four weeks
at a dose of 45 mg/kg, dissolved in 0.1% DMSO |
Tumor volume reduction |
(53) |
Berberine
|
Berberis
vulgaris
|
-
|
IC50 = 25 µM
|
Cell cycle arrest induction, drug-drug interactions, dose-dependent
tumor volume decrease, and angiogenesis
|
(54)
|
Combretastatin
|
Combretum
caffrum
|
mice
|
IC50 = 80-190 µM
|
Tubulin binding results in the microtubules being less stable
|
(55)
|
Ginkgetin |
Ginkgo biloba |
mouse |
IC50 = 10 µM |
Autolysosome
production and redox environment are mediated by p62/SQSTM1, and the
signaling transducer and activator of transcription 3 activity is
inhibited |
(56) |
Noscapine
|
Papaver
somniferum
|
mice
|
IC50 = 45 µM
|
Triggering several signaling cascades, such as apoptosis
|
(57)
|
Cryptotanshinone
|
Salvia prionitis
|
mice
|
IC50 = 1.1 µM
|
Multifaceted mechanisms of action include apoptosis, G2/M arrest, and
cellular movement inhibition.
All these pathways are orchestrated by NFB inhibition
|
(58)
|