Drug Classes Active Compounds Common side effects*
Antimetabolites 5’-triphosphate, 5-Fluorouracil, Deoxyadenosine, 1-β-D-arabinofuranoside, Mercaptopurine, Gemcitabine diphosphate and triphosphate, 5-Fluorouracil, 9-beta-D-arabinosyl-2-fluoroadenine, 6-Mercaptopurine, Methotrexate, 6-Thioguanosine, 5-Fluorouracil, Methyl-tetrahydrofolate Leucovorin Bleeding and Bruising (Thrombocytopenia), Anemia, Delirium loss, Constipation, Appetite, Diarrhea, Fatigue (Swelling), Edema
Alkylating agents Busulfan, Carmustine, Acrolein and phosphoramide mustard, 5-aminoimidazole-4-carboxamide, Lomustine, Mechlorethamine, Melphalan, Azo-Procarbazine, Triethylenethio-phosphoramide, Semustine Nausea and vomiting
Anthracyclines Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mitoxantrone Severe cough allergic, Photosensitivity, Hoarseness of voice, Skin and nail hyperpigmentation, Flushing of the face, Allergic reactions (anaphylaxis), Fatigue, Joint pain
Antitumor antibiotic Bleomycin, Dactinomicyn, Mitomycin, Plicamycin Feeling of unwellness (malaise) rash, Fatigue, Fever and chills, Hair loss, Diarrhea, Nausea or vomiting, Loss of appetite
Epipodophyllotoxins Etoposide, Teniposide Nausea, Unusual tiredness or weakness, Constipation, Stomach pain, Diarrhea, Sores in the mouth and throat, Loss of appetite or weight, Vomiting
Taxanes Cabazitaxel, Docetaxel, Paclitaxel Fatigue at the IV site, Muscle aches and pains, Called myalgia, which can be extreme. Redness or swelling, Skin rashes, Nausea and vomiting, Hair loss, Mouth sores. Joint or bone pain
Vinca alkaloids Vinblastine, Vincristine, Vinorelbine Nausea, Diarrhea, Constipation, Tiredness/weakness, Abdominal pain, Headache, Mouth sores, Vomiting
Campotothecins SN-38 (7-ethyl-10-hydroxycamptothecin), Topotecan Diarrhea, Constipation, Back pain, Tiredness/weakness, Headache, Nausea, Vomiting, Abdominal pain
Platinum analogs Carboplatin, Cisplatin, Oxaliplatin Headache, Vomiting, Constipation, Nausea, Mouth sores, Altered taste sensation, Abdominal pain, Diarrhea.
Monoclonal antibody Bevacizumab, Cetuximab, Rituximab, Trastuzumab Nausea, Allergic reactions such as hives or itching, Diarrhea, including chills, Fatigue, Fever, Muscle aches and pains, Allergic reactions, Vomiting, Low blood pressure, Skin rashes, Flu-like signs and symptoms
Growth inhibitor
Axitinib, Bortezomib, Sunitinib, Crizotinib, Lapatinib, Dasatinib, Imatinib, Dabrafenib, Nilotinib, Bosutinib, Sorafenib, Pazopanib, Trametinib, Vandetanib, Vemurafenib
Coughing up blood, Depressed mood, Chest tightness. Clay colored stools, Cloudy urine, Bleeding gums, Decreased urination, Bloody nose