Predictive factors for a second cycle of propranolol therapy
Fourteen patients required a second round of propranolol for regrowth after stopping their first round. Fifty-seven percent of patients who required a second cycle of propranolol had a partial response to the first cycle of propranolol (Table 4). For this subset of patients, the mean length of the first cycle of propranolol treatment was 7.6 months. After controlling for hemangioma location, we found that patients with a positive family history of hemangiomas or cardiac abnormalities were 3.6 times more likely to need a second round of propranolol treatment (OR, 3.6; 95% Confidence Interval (CI) 1.14-11.19) (P=0.03).