Main findings
We evaluated 69,001 parturients for a median time of 4.27 years
follow-up. In concomitant with the available data, our findings,
demonstrated that maternal age, BMI≥ 30 Kg/m2, GDM,
and FPG levels were all independent predictors for T2DM. Furthermore, we
observed that the incidence of T2DM increased in tandem with rising FPG
levels during the 1st trimester of pregnancy, even when these levels
fell within the normal range, irrespective of maternal obesity status.
Moreover, our study indicated that FPG levels exceeding 86.5 mg/dl
during 1st trimester were comparable to GDM in
predicting the onset of T2DM, although both demonstrated moderate
predictive capabilities. Interestingly, 1st trimester
FPG levels had higher prediction performance for T2DM, as compared to
GDM, especially for women with BMI<30 Kg/m2.