Characteristics of the study population
Our dataset included 125,457 women with LMP during the study period and T2DM follow-up. After excluding all repeated pregnancies, women without 1st trimester FPG results or FPG levels over 125 mg/dl, we were left with 69,001 women with available 1st trimester FPG values and INDR data that entered analysis (Figure S1).
For the entire cohort, the median follow-up time was 4.27 years (Interquartile range (IQR) 3.25-5.08).
Maternal characteristics, glucose levels during pregnancy, and future T2DM diagnosis stratified by 1st trimester FPG levels, with increments of 10 mg/dl are presented in Table 1. Women with higher FPG levels in 1st trimester were older, with higher BMI, and had a higher proportion of hypertension and glucose levels throughout pregnancy (at GCT and all oGTT values), p<0.001 for all. Obstetrically, higher FPG was associated with decreased gestational age at delivery.