Entry |
[Ni] |
Base |
[H] source |
Solvent |
L |
Yield
of 5a (%)b
|
ee of 5a
(%)c
|
1 |
Ni(COD)2
|
DABCO |
HBpin |
Toluene |
(RP)-L1
|
92 |
97 |
2 |
Ni(OTf)2
|
DABCO |
HBpin |
Toluene |
(RP)-L1
|
<5 |
- |
3 |
Ni(OAc)2
|
DABCO |
HBpin |
Toluene |
(RP)-L1
|
<5 |
- |
4 |
Ni(COD)2
|
DBU |
HBpin |
Toluene |
(RP)-L1
|
40 |
15 |
5 |
Ni(COD)2
|
DIPEA |
HBpin |
Toluene |
(RP)-L1
|
93 |
92 |
6 |
Ni(COD)2
|
DABCO |
CB |
Toluene |
(RP)-L1
|
<5 |
- |
7 |
Ni(COD)2
|
DABCO |
Ph2SiH2
|
Toluene |
(RP)-L1
|
<5 |
- |
8 |
Ni(COD)2
|
DABCO |
HBpin |
Et2O |
(RP)-L1
|
99 |
95 |
9 |
Ni(COD)2
|
DABCO |
HBpin |
DCM |
(RP)-L1
|
97 |
94 |
10 |
Ni(COD)2
|
DABCO |
HBpin |
EA |
(RP)-L1
|
92 |
97 |
11 |
Ni(COD)2
|
DABCO |
HBpin |
iPrOH |
(RP)-L1
|
<5 |
- |
12 |
Ni(COD)2
|
DABCO |
HBpin |
Toluene |
(RP)-L2
|
99 |
98 |
13 |
Ni(COD)2
|
DABCO |
HBpin |
Toluene |
(RP)-L3
|
99 |
96 |
14 |
Ni(COD)2
|
DABCO |
HBpin |
Toluene |
(RP)-L4
|
99 |
97 |
15 |
Ni(COD)2
|
DABCO |
HBpin |
Toluene |
(RP)-L5
|
96 |
96 |
16 |
Ni(COD)2
|
DABCO |
HBpin |
Toluene |
(RP)-L6
|
91 |
7 |
17 |
Ni(COD)2
|
DABCO |
HBpin |
Toluene |
(RP)-L7
|
89 |
82 |
18 |
Ni(COD)2
|
DABCO |
HBpin |
Toluene |
(RP)-L8
|
98 |
98 |
19 |
Ni(COD)2
|
DABCO |
HBpin |
Toluene |
(RP)-L9
|
<5 |
- |
20 |
Ni(COD)2
|
DABCO |
HBpin |
Toluene |
(RP)-L10
|
87 |
95 |