REFERENCES
1. Barr RD, Stevens MC. The influence of nutrition on clinical outcomes
in children with cancer. Pediatric Blood Cancer 2020;67 Suppl 3: e28117.
2. Orgel, E, Genkinger, JM, Aggarwal, D, Sung, L, Nieder, M, and Ladas,
EJ. Association of body mass index and survival in pediatric leukemia: a
meta-analysis. Am J Clin Nutr. (2016) 103:808–17. doi:
10.3945/ajcn.115.124586
3. Kleinman RE, Pediatric Nutrition. American Academy of Pediatrics.
Nutrition ACo. Section Micronutrients & Macronutrients 8th ed. Itasca:
American Academy of Pediatrics. 2019.
4. Ganguly S, Srivastava R, Agarwala S, Dwivedi S, Bansal PG, Gonmei Z,
et al. Prevalence of
micronutrient deficiency and its impact on the outcome of childhood
cancer: A prospective
cohort study. Clin Nutr 2022;41:1501–11. https://doi.org/
10.1016/j.clnu.2022.05.010.
5. Podpeskar A, Crazzolara R, Kropshofer G, Hetzer B, Rabensteiner E,
Meister B, Obexer P, Salvador C. Recommendations for Nutritional
Supplementation in Pediatric Oncology: A Compilation of the Facts.
Nutrients. 2023 Jul 21;15(14):3239.
https://doi.org/10.3390/nu15143239
6. Iniesta RR, Gerasimidis K, Paciarotti I, McKenzie JM, Brougham MF,
Wilson DC. Micronutrient status influences clinical outcomes of
paediatric cancer patients during treatment: a prospective cohort study.
Clinical Nutrition. 2021 May 1;40(5):2923-35.
7. Wessels G, Hesseling PB, Stefan DC, Labadarios D. The effect of
vitamin A status in children treated for cancer. Pediatric Hematology
and Oncology. 2008 Jan 1;25(4):283-90.
8. Oosterom N, Dirks NF, Heil SG, de Jonge R, Tissing WJ, Pieters R, van
den Heuvel-Eibrink MM, Heijboer AC, Pluijm SM. A decrease in vitamin D
levels is associated with methotrexate-induced oral mucositis in
children with acute lymphoblastic leukemia. Supportive Care in Cancer.
2019 Jan;27:183-90.
9. Sinha A, Avery P, Turner S, Bailey S, Cheetham T. Vitamin D status in
paediatric patients with cancer. Pediatric blood & cancer.
2011;57(4):594-8.
10. Jackmann N, Mäkitie O, Harila-Saari A, Gustafsson J, Nezirevic
Dernroth D, Frisk P. Vitamin D status in children with leukemia, its
predictors, and association with outcome. Pediatric blood & cancer.
2020;67(4):e28163.
11. Schoeman J, Kellerman I-M, Rogers PC, Ladas EJ, Lombard CJ, Uys R,
Kruger M. Prevalence of vitamin and iron deficiencies at cancer
diagnosis at two pediatric oncology units in South Africa. Pediatr
Hematol Oncol 2023:20;1-14. DOI:10.1080/0880018.2023.2188920
12. Chung JH, Phalke N, Hastings C, Killilea DW, Feusner JH, Fung EB.
Zinc deficiency and its association with treatment-related toxicity in
children with cancer. Pediatr Blood Cancer. 68.9 2021; DOI: 10.1002/
pbc.29104
13. Shimada BK, Alfulaij N, Seale LA. The impact of selenium deficiency
on cardiovascular function. International Journal of Molecular Sciences.
2021 Oct 2;22(19):10713
14. Stevens J, Waters R, Sieniawska C, Kassam S, Montoto S, Fitzgibbon
J, et al. Serum selenium concentration at diagnosis and outcome in
patients with haematological malignancies. Br J Haematol. 2011; 154:
448- 456. DOI: 10.1111/j.1365-2141.2011.08744.x
15. Lelièvre P, Sancey L, Coll JL, Deniaud A, Busser B. The multifaceted
roles of copper in cancer: A trace metal element with dysregulated
metabolism, but also a target or a bullet for therapy. Cancers. 2020 Dec
1;12(12):3594.
16.Pace A, Giannarelli D, Galie E, et al. Vitamin E neuroprotection for
cisplatin neuropathy: a randomized, placebo-controlled trial. Neurology.
2010;74(9):762–766.
17.Neil EC, Hanmantgad S, Khakoo Y. Neurological complications of
pediatric cancer. Journal of child neurology. 2016 Oct;31(12):1412-20.
18. Faber S, Cutler EC, Hawkins JW, Harrison JH, Peirce EC, Lenx GG. The
action of pteroylglutamic conjugates on man. Science 1947, 106, 619-621
19.Farber S, Diamond LK, mercer RD, Sylvester RF, Wolff VA. Temporary
remission of acute leukemia in children produced by folic acid
antagonist, 4-aminopteroyl glutamic acid (aminopterin). 1948 N Engl J
Med,238,787-793
20. Deborah D. Kennedy, Elena J. Ladas, Susan R. Rheingold, Jeffrey
Blumberg, Kara M. Kelly, Antioxidant status decreases in children with
acute lymphoblastic leukemia during the first six months of chemotherapy
treatment, Pediatric Blood & Cancer, 2004. 44, 4, (378-385)
21. Fuchs-Tarlovsky V. Role of antioxidants in cancer therapy.
Nutrition. 2013 Jan 1;29(1):15-21.
22.Ames BN. DNA damage from micronutrient deficiencies is likely to be a
major cause of cancer. Mutation research/fundamental and molecular
mechanisms of mutagenesis. 2001 Apr 18;475(1-2):7-20.
23.Methyl Donor Micronutrients that Modify DNA Methylation and Cancer
Outcome Nutrients 2019, 11(3),
608; https://doi.org/10.3390/nu11030608
24.Cooney CA, Dave AA, Wolff GL. Maternal methyl supplements in mice
affect epigenetic variation and DNA methylation of offspring. J
Nutr. 2002; 132(8 Suppl): 2393S-2400S.
25. Goh, Y. I., Bollano, E., Einarson, T. R., & Koren, G. (2007).
Prenatal multivitamin supplementation and rates of pediatric cancers: a
meta-analysis. Clinical pharmacology and therapeutics, 81(5), 685–691.
https://doi.org/10.1038/sj.clpt.6100100
26. Trujillo E, Davis C, Milner J. Nutrigenomics, proteomics,
metabolomics, and the practice of dietetics. J Am Diet
Assoc. 2006; 106 : 403-413.
27.Barone, M, D’Amico, F, Brigidi, P, Turroni, S. Gut
microbiome–micronutrient interaction: The key to controlling the
bioavailability of minerals and
vitamins? BioFactors. 2022; 48: 307–314. https://doi.org/10.1002/biof.1835
28.Wang K, Yang T, Zhang Y, Gao X, Tao L. The opportunities and
challenges for nutritional intervention in childhood cancers. Frontiers
in Nutrition. 2023 Feb 13:10:1091067.
29.Rogers, P. C. and Barr, R. D. (2020). The relevance of nutrition to
pediatric oncology: a cancer control perspective. Pediatric Blood &
Cancer, 2020, 67(S3). https://doi.org/10.1002/pbc.28213
Table 1. Physical characteristics of the patient cohort at diagnosis and
at 6 months. The median
(95% confidence interval) are reported.