Round 1 Round 1 Round 1 Round 1 Round 1 Round 2 Round 2 Round 2 Round 2 Final Final Final
IgE IgE IgE Non-IgE Non-IgE IgE Non-IgE Non-IgE Non-IgE IgE IgE Non-IgE
n 14 14 14 14 14 (4) (3) (3) (3) 12 12 7
Skin symptoms
Rash, redness of skin
Rash, redness of skin
Rash, redness of skin
Rash, redness of skin
Rash, redness of skin
Worsening of eczema (new flare) <2 hours
Worsening of eczema (new flare) <2 hours
Rough or bumpy, itchy skin Rough or bumpy, itchy skin Rough or bumpy, itchy skin
New eczema flare New eczema flare New eczema flare Worsening of eczema (new flare) 2-24 hours
Hives (nettle rash) Hives (nettle rash) Hives (nettle rash) Hives (nettle rash) Hives (nettle rash) Hives (nettle rash) < 2 hours Hives (nettle rash) < 2 hours
Itching Itching Itching Itching Itching Itching < 2 hours Itching < 2 hours Itching 2 hours to 2 days
Swelling around the lips, face or eyes Swelling around the lips, face or eyes Swelling around the lips, face or eyes Swelling around the lips, face or eyes Swelling around the lips, face or eyes Swelling around the lips, face or eyes < 2 hours Swelling around the lips, face or eyes < 2 hours
Gut symptoms
Diarrhoea
Diarrhoea
Diarrhoea
Diarrhoea
Diarrhoea
Diarrhoea <24 hours
Diarrhoea <24 hours
Diarrhoea 2 hours to 2 days
Constipation Constipation Constipation Constipation Constipation Constipation 1-2 days
Abdominal pain/ bloating (incl. ‘colic’) Abdominal pain/ bloating (incl. ‘colic’) Abdominal pain/ bloating (incl. ‘colic’) Abdominal pain/ bloating (incl. ‘colic’) Abdominal pain/ bloating (incl. ‘colic’) Abdominal pain Abdominal pain < 2 hours Abdominal pain < 2 hours Abdominal pain 1-2 days
Blood and/or mucus in poo Blood and/or mucus in poo Blood and/or mucus in poo Blood and/or mucus in poo Blood and/or mucus in poo Blood and/or mucus in poo 1-2 days
Vomiting Vomiting Vomiting Vomiting Vomiting Vomiting <2 hours Vomiting <2 hours Vomiting 2 hours to 2 days
Airways symptoms
Coughing
Coughing
Coughing
Coughing
Coughing
Coughing <2 hours
Coughing <2 hours
Wheezing Wheezing Wheezing Wheezing Wheezing Wheezing <2 hours Wheezing <2 hours
Noisy or difficulty breathing Noisy or difficulty breathing Noisy or difficulty breathing Noisy or difficulty breathing Noisy or difficulty breathing Hoarse voice or cry Hoarse voice or cry <2 hours Hoarse voice or cry <2 hours
Swelling of tongue or airway/ stridor Swelling of tongue or airway/stridor <2 hours Swelling of tongue or airway/stridor <2 hours
Sneezing Sneezing Sneezing Sneezing Sneezing Sneezing <2 hours Sneezing <2 hours
Nasal congestion or runny nose Nasal congestion or runny nose Nasal congestion or runny nose Nasal congestion or runny nose Nasal congestion or runny nose Nasal congestion or runny nose Nasal congestion or runny nose Nasal congestion or runny nose Nasal congestion or runny nose
Key: Key: Consensus – include Consensus – include Not consensus Not consensus Consensus – exclude Consensus – exclude