Figure 4. Proteomic alterations observed across N.
gonorrhoeae strains expressing different pglO alleles compared
to pglOmeningitidis. A) Upset plot of
proteome alterations compared to pglOmeningitidisreveal 76 protein alterations between different alleles. B)Heatmap of unsupervised clustered z-scored alterations support differentpglO alleles lead to different proteomic effects with changes in
membrane proteins highlighted in blue, transporters, highlighted in red
and the single glycoprotein differentially impacted (NGO_1577)
highlighted in green. Unsupervised clustering of biological replicates
denoted by coloring of the dendrogram branches.