3.2. Absolute Neutrophil Count Analysis
When assessing the percentage time spent in therapeutic ANC range for the allopurinol cohort before and after initiation of allopurinol, there was a significant increase in the median percentage of time spent within the therapeutic ANC range after allopurinol was initiated (median (IQR); 27% (15-58) vs. 43% (26-55); P= 0.03). Patients in the allopurinol cohort prior to allopurinol initiation had a similar percentage of time spent in therapeutic ANC range when compared to patients in the standard treatment cohort (median (IQR); 27% (15-58) vs. 29% (20-53); P= 0.68). Median time spent in therapeutic ANC range was greater within the allopurinol cohort after allopurinol initiation when compared to patient in the standard treatment cohort. (median (IQR); 43% (26-55) vs. 29% (23-53); P= 0.08) (Table 4 and Figure 2).