3.2. Absolute Neutrophil Count Analysis
When assessing the percentage time spent in therapeutic ANC range for
the allopurinol cohort before and after initiation of allopurinol, there
was a significant increase in the median percentage of time spent within
the therapeutic ANC range after allopurinol was initiated (median (IQR);
27% (15-58) vs. 43% (26-55); P= 0.03). Patients in the
allopurinol cohort prior to allopurinol initiation had a similar
percentage of time spent in therapeutic ANC range when compared to
patients in the standard treatment cohort (median (IQR); 27% (15-58)
vs. 29% (20-53); P= 0.68). Median time spent in therapeutic ANC
range was greater within the allopurinol cohort after allopurinol
initiation when compared to patient in the standard treatment cohort.
(median (IQR); 43% (26-55) vs. 29% (23-53); P= 0.08) (Table 4
and Figure 2).