3.4. 6MP-Related Toxicity Analysis
Patients in the allopurinol cohort who were initiated on allopurinol for
hepatotoxicity, with or without inadequate myelosuppression, had
significantly decreased AST, ALT, total bilirubin, and direct bilirubin
values 12 weeks after initiating allopurinol (P= 0.002,P= 0.0006, P= 0.005, and P= 0.006, respectively)
(Table 5 (Figure 3) For patients started on allopurinol, 100% (n=4) of
patients with rash, 85% (n=6) of patients with GI upset, and 80% (n=4)
of patients with other clinical reasons obtained had complete resolution
of their specific symptoms by 12 weeks post-allopurinol initiation.