Characteristic
Allopurinol (n=32) No Allopurinol (n=63)
P-Value
Age at start of maintenance (years), median (range) 7 (1–17) 5 (2–17) 0.3
Weight (kg), median (range) 26.9 (10.2–128) 20.9 (11–88.7) 0.2
BSA (m2), median (range) 0.99 (0.48–2.55) 0.81 (0.51–1.98) 0.2
Sex, number (%) Sex, number (%) Sex, number (%) 0.29
Female
18 (56)
28 (44)
Male
14 (44)
35 (56)
Race, number (%) Race, number (%) Race, number (%)
White
18 (56)
38 (60)
0.52
Black
7 (22)
8 (13)
Other
7 (22)
15 (24)
Asian
0 (0)
2 (3)
Ethnicity, number (%) Ethnicity, number (%) Ethnicity, number (%) 0.62
Non-Hispanic/Latino
25 (78)
45 (71)
Hispanic/Latino
7 (22)
18 (29)
Trisomy 21 (DS), number (%) 1 (3) 4 (6) 0.58
TPMT genotype, number (%) TPMT genotype, number (%) TPMT genotype, number (%) 0.13
*1/*1
20 (63)
43 (68)
*1/*3A or *1/*3C
2 (6)
10 (16)
Not genotyped
10 (31)
10 (16)
NUDT15 genotype, number (%) NUDT15 genotype, number (%) NUDT15 genotype, number (%) 0.7
*1/*1
16 (50)
28 (44)
*1/*4
0 (0)
1 (2)
Not genotyped
16 (50)
34 (54)
TPMT phenotype, number (%) TPMT phenotype, number (%) TPMT phenotype, number (%) 0.12
Low
1 (3)
1 (2)
Intermediate
1 (3)
12 (19)
High (normal)
28 (88)
49 (77)
Not collected
2 (6)
1 (2)
NUDT15 phenotype, number (%) NUDT15 phenotype, number (%) NUDT15 phenotype, number (%) 0.7
Normal
16 (50)
29 (46)
Intermediate
0 (0)
1 (2)
Not collected
16 (50)
33 (52)
Diagnosis, number (%) Diagnosis, number (%) Diagnosis, number (%) 0.73
T-Cell ALL
28 (88)
57 (90)
B-Cell ALL
4 (12)
6 (10)
Risk status, number (%) Risk status, number (%) Risk status, number (%) 0.65
Standard
16 (50)
31 (49)
Intermediate
3 (9)
3 (5)
High
13 (41)
29 (46)
6MP dosage form, number (%) 6MP dosage form, number (%) 6MP dosage form, number (%) 0.82
Tablet
21 (66)
43 (68)
Oral Solution
11 (34)
20 (32)
Starting daily dose of 6MP (mg/m2/day), median (range) 75 (71–77) 75 (38–78) 0.58
Abbreviations: 6MP, 6-mercaptopurine; ALL, acute lymphoblastic leukemia; BSA, body surface area; DS, Down syndrome; NUDT15, nudix hydrolase 15 gene; TPMT, thiopurine methyltransferase gene. Abbreviations: 6MP, 6-mercaptopurine; ALL, acute lymphoblastic leukemia; BSA, body surface area; DS, Down syndrome; NUDT15, nudix hydrolase 15 gene; TPMT, thiopurine methyltransferase gene. Abbreviations: 6MP, 6-mercaptopurine; ALL, acute lymphoblastic leukemia; BSA, body surface area; DS, Down syndrome; NUDT15, nudix hydrolase 15 gene; TPMT, thiopurine methyltransferase gene. Abbreviations: 6MP, 6-mercaptopurine; ALL, acute lymphoblastic leukemia; BSA, body surface area; DS, Down syndrome; NUDT15, nudix hydrolase 15 gene; TPMT, thiopurine methyltransferase gene.