Markers of Hepatotoxicity
Pre-allopurinol (n=14) Post-allopurinol (n=14)
P-Value
AST (U/L), median (range) 197.8 (62.0–1032.0) 122 (22.8–261.0) 0.002
ALT (U/L), median (range) 136.7 (30.7–573.0) 51.7 (24.0–119.0) 0.0006
Total bilirubin (mg/dL), median (range)
1.70 (0.18–9.08)
0.94 (0.13–1.77)
0.005
Direct bilirubin (mg/dL), median (range)
0.60 (0.10–7.88)
0.20 (0.10–0.52)
0.006
Abbreviations: ALT, alanine aminotransferase, AST; aspartate aminotransferase Bold text = statistical significance with a P-value <0.05 Abbreviations: ALT, alanine aminotransferase, AST; aspartate aminotransferase Bold text = statistical significance with a P-value <0.05 Abbreviations: ALT, alanine aminotransferase, AST; aspartate aminotransferase Bold text = statistical significance with a P-value <0.05 Abbreviations: ALT, alanine aminotransferase, AST; aspartate aminotransferase Bold text = statistical significance with a P-value <0.05