3.4. 6MP-Related Toxicity Analysis
Patients in the allopurinol cohort who were initiated on allopurinol for hepatotoxicity, with or without inadequate myelosuppression, had significantly decreased AST, ALT, total bilirubin, and direct bilirubin values 12 weeks after initiating allopurinol (P= 0.002,P= 0.0006, P= 0.005, and P= 0.006, respectively) (Table 5 (Figure 3) For patients started on allopurinol, 100% (n=4) of patients with rash, 85% (n=6) of patients with GI upset, and 80% (n=4) of patients with other clinical reasons obtained had complete resolution of their specific symptoms by 12 weeks post-allopurinol initiation.