cappello ispirato a discussione dei monospeophills in SCID
    Bone is a tissues highly re-modeled during the entire life and preserving a consistent capacity of healing an regeneration in response to injuries also in the adulthood. Both re-modeling (cit) and regeneration (cit) processes are orchestrated within specialized anatomical structures involving complex interactions between cells, soluble factors and extracellular matrix. The cell compartment involved in mantaining or restoring bone homeostasis is divide in "calciyfing/bone forming" or "bone resorbing" cells. Mesenchyme-derived cells as MSC, chondroblasts, osteoblast and osteocytes partecipate to the calcification process, while hemopoietic-derived osteoclasts are commonly exclusively associated to bone resorption. However, increasing amount of evidences points to the mesengenic potential of BM-derived hemopoietic cells, which could a have a role also in the new bone formation. Moreover, in response to injuries, not only resident bone and bone marrow cells has been indicated being involved in regeneration but also circulating cells has been hypothesized able to engraft and partecipate to the calcification process. 
Mesengenic potential in the circulating hemopoietic compartment
CD14 mono derived multipotent:
MOMC
kuwana seta okazaki
stout TAM 2009
PCMO
Monosteophils.
Fadini MCC 2012
COP Suda 2009 
matsumoto epc 2006 2008
BM resident mac
Multi-nucleated Giant Cells (MNGCs)