Summary
Sepsis is a life-threatening heterogeneous syndrome due to a
dysregulated immune response to infection. Studies have shown that
genetic polymorphisms might have impact on the risk of sepsis.LincRNA-NR_024015 , also known as testis development related
1(TDRG1 ), is a newly identified long non-coding RNA (lncRNA). It
has been found to participate in vascular endothelial growth factor
(VEGF) signaling in human diseases, but its relevance in the development
of sepsis is still unclear. In the present study, we genotyped lncRNATDRG1 rs8506 polymorphism in 474 patients and 678 healthy
controls recruited from a southern Chinese child population using Taqman
methodology. Overall, a significant association was found between rs8506
polymorphism and the risk of sepsis disease (TT vs . CC/CT:
adjusted OR = 1.751, 95%CI = 1.024–2.993, P = 0.0406). In the
stratified analysis, the results suggested that the carriers of TT
genotypes had a significantly increased sepsis risk among the children
aged 12–60 months, females, early-stage sepsis and survivors (TTvs. CC/CT: ORage = 2.413;
ORfemale = 2.868; ORsepsis = 2.533;
ORsurvivor = 1.822; adjusted for age and gender,P < 0.05, respectively). Our study indicated that
lncRNA TDRG1 rs8506 TT genotype might contribute to the risk of
sepsis in a southern Chinese child population. Future research is
required to elucidate the possible immunoregulatory mechanisms of this
association.