Bupropion effect on the gene expression of TLR2 and TLR4
TLRs are key components of innate immunity and orchestrate immune
responses by inducing the production of many cytokines. Concerning the
recognized role of TLR2, TLR4 in depression, and as the representative
of innate and adaptive immunity we focused on TLR2, TLR4 signaling
pathways. Bupropion addition to LPS-treated PBMCs significantly
increased gene expression of both receptors (Fig. 3).