Principal investigator statement
The authors confirm that the PI for this paper is Alireza Karimollah and
that he had direct clinical responsibility for patient.
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What is already known about this subject?
- A considerable proportion of depressed patients do not respond to the
common antidepressant therapy.
- Inflammation is linked to the depression pathophysiology and
inflammatory status prior to the treatment determines the success of
medication in some MDD patients.
- Bupropion is a common-used antidepressant with the confirmed
immunomodulatory properties.
What this study adds:
- This study revealed that despite the attributed anti-inflammatory
properties to bupropion, it enhances gene expression of
pro-inflammatory cytokines including IL-1ß, TNF-ɑ, and IL-17A.
- Bupropion upregulates gene expression of TLR2, TLR4 and JAK2/STAT3
signaling molecules.
- Bupropion would better get administrated with anti-inflammatory
agents.