Bupropion effect on the gene expression of TLR2 and TLR4
TLRs are key components of innate immunity and orchestrate immune responses by inducing the production of many cytokines. Concerning the recognized role of TLR2, TLR4 in depression, and as the representative of innate and adaptive immunity we focused on TLR2, TLR4 signaling pathways. Bupropion addition to LPS-treated PBMCs significantly increased gene expression of both receptors (Fig. 3).