Dose-related effects of bupropion
Based on our findings, bupropion immunomodulatory effect varied depending on the concentration. Results demonstrated that bupropion exerts the most inflammatory action in 50 and 100 μM evidenced by a sharp increase in mRNA levels of target pro-inflammatory cytokines (TNF-ɑ, IL-1ß, and IL-17) and considerable upregulation of TLR2, TLR4, JAK2, and STAT3 genes.