Exhaled 15-HETE and thromboxin-B2 are associated with therapeutic outcome in childhood asthma
Li-Chen Chen, MD1,2,3, Hsu-Min Tseng, PhD4, Ming-Ling Kuo, PhD1, 2,5, Chih-Yung Chiu, MD, PhD3,7, Sui-Ling Liao, MD 3,6, Kuan-Wen Su, MD 3,6, Ming-Han Tsai, MD, PhD 3,6, Man-Chin Hua, MD3,6, Shen-Hao Lai, MD 3,7, Tsung-Chieh Yao, MD 2,3, Kuo-Wei Yeh, MD2,3, Ai-Hsuan Wu, MS1,2, Hsiu-Yueh Yu, MS1,2, Jing-Long Huang, M.D1,2,3* and Shau-Ku Huang, PhD8,9*
1Department of Pediatrics, New Taipei Municipal TuCheng Hospital, New Taipei, Taiwan, 2 Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan,; 3Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan;4Department of Healthcare Management, Chang Gung University, Taoyuan, Taiwan; 5Department of Microbiology and Immunology, Graduate Institute of Basic Medical Research, Chang Gung University, Taoyuan, Taiwan;6Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; 7Division of Pediatric Pulmonology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 8National Institute of Environmental Health Sciences, National Health Research Institutes, Zhunan, Taiwan; 9Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, USA
Correspondence: Jing-Long Huang, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan, Email:hjlong0182@gmail.com; Shau-Ku Huang, National Health Research Institutes, Zhunan, Taiwan. Email:skhuang1@gmail.com
* JLH and SKH contributed equally.
Funding information This work was supported, in part, by Chang Gung Memorial Hospital (CMRPG3G2051, CMRPVVK0161)., the Ministry of Science and Technology, Taiwan (MOST 108-2314-B-182A-088) and, in part, by a grant from National Health Research Institutes, Taiwan (EO-109-PP-10).
CONFLICT OF INTEREST
The authors declare that they have no conflict of interests
AUTHOR CONTRIBUTIONS
It was the responsibility of Li-Chen Chen to conceive, organize, and implement the research protocol, as well as to interpret the data, guide discussions of the results, and draft the manuscript. Chih-Yung Chiu, Sui-Ling Liao, Kuan-Wen Su, Ming-Han Tsai, Man-Chin Hua, ShenHao Lai, Tsung-Chieh Yao, and Kuo-Wei Yeh were responsible for the recruitment of study subjects and clinical data evaluation. AiHsuan Wu, Hsu-Min Tseng, and Ming-Ling Kuo participated in the experiment and data analysis. With regards to the corresponding authors, Jing-Long Huang coordinated the study and interpreted the data, while Shau-Ku Huang supervised the research program and contributed to the design and manuscript writing. All authors had an opportunity to edit the manuscript and all approved of its submission.