Significance of 25-(OH)D deficiency through subgroup analysis
Stratified subgroup analyses were conducted according to age (≤ 60 years, > 60 years), gender (male, female), EBV infection status (negative, positive), pathogensis(MHLH,non-MHLH), hemoglobin (<90g/L, ≥90g/L), platelet (<100×109/L, ≥100×109/L), Fib (<1.5 g/l, ≥1.5g/l), TG (<3mmol/L, ≥3mmol/L), ferritin (≤10000 ug/L, >10000 ug/L), sCD25 (≤20000ng/l, >20000ng/l). 25-(OH)-D had a significant interaction with ferritin (P =0.009), and vitamin D was an important protective factor for ferritin>10000ug/L (HR=0.052(0.005-0.590),P =0.017). Although there were no significant interactions for the associations between 25-(OH)-D and survival across strata by other variables, vitamin D was more likely to predictive of survival in older, male, MHLH, EBV infection, hemoglobin<90g/L, platelet<100×109/L, Fib <1.5g/L, triglyceride, sCD25>20000ng/l group (Table 3).