Association with 25-(OH)-D and prognosis
Upon final follow-up (February 1, 2021), the mortality rate was 83.3%.
Median OS of the cohort group was 42 days (range: 1-669 days). As shown
in Figure 2, patients with low vitamin D level acquired lower overall
survival compared to those with high level (28 vs. 125 daysP =0.041). In table 2, univariate KM or Cox analysis demonstrated
that hemoglobin, platelet, albumin, TG, β2 -MG, ferritin,
loge (sCD25) was significantly predictive for survival
(P <0.05). Then, we transferred those indexes withP < 0.05 into multivariate Cox regression analysis to
screen out independent risk factors of OS. The result demonstrated that
vitamin D was an independent factor for OS HR=0.364 ;95% CI
0.183-0.724; P = 0.004). Also, inferior survival engaged other
four factors:
loge(sCD25)(HR=2.291;95%CI=1.186-4.426;P =0.014);
ß2-MG (HR=1.093;95%CI=1.017-1.174;P =0.015); platelet (HR=0.983;
95%CI=0.971-0.996; P =0.008) .