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\begin{document}

\title{Clinical characteristics of Castleman disease in head and neck}



\author[1]{Jun WU}%
\author[1]{Jingkun LI}%
\author[1]{Xi WU}%
\author[1]{Lijuan MA}%
\affil[1]{Hunan Province}%


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  \date{May 24, 2024}


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\begin{abstract}
Objective: This study was performed to investigate the clinical and
pathological manifestations of Castleman disease in head and neck, and
to summarize its clinical characteristics, experiences of diagnosis and
treatment, and prognosis of patients.~STUDY DESIGN: Retrospective study.
SETTING: Hunan Provincial People's Hospital. Methods: We retrospectively
analyze the clinical data of 8 patients suffering from Castleman disease
in head and neck who received treatment in Hunan people's Hospital
between 2013.1 to 2020.07, and review the relevant literature.~Results:
7 of the 8 patients were characterized by single or multiple painless
masses in head and neck. They were categorized as unicentric Castleman
disease (UCD). Case 8 was clinically classified as multicentric
Castleman's disease (MCD) because the neck mass of this patient was
found with discomfort such as anemia, fatigue and fever. The
pathological types were hyaline-vascular type (HVT) in 6 patients, mixed
type in 1 patient and the plasma cell type (PCT) in 1 patient. All the
patients were operated to remove the mass and showed no recurrence in
the following up for 4-93 months.~Conclusions: The diagnosis of
Castleman disease in head and neck should be confirmed by pathological
examination. UCD is the main type in the clinical classification, and
HVT is the main type in pathological. Surgical resection of the mass can
be an effective treatment, and proper medical therapy should be
supplemented to those with postoperative recurrence. The patients with
UCD generally have a good prognosis. {[}KEY WORDS{]} Head and neck;
Castleman disease; Diagnosis; Treatment%
\end{abstract}%



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