Experimental Groups (n=10)
Experimental Groups (n=10)
Physical deterioration after 36 days post-implantation (Number of affected animals) a Physical deterioration after 36 days post-implantation (Number of affected animals) a Physical deterioration after 36 days post-implantation (Number of affected animals) a Physical deterioration after 36 days post-implantation (Number of affected animals) a Physical deterioration after 36 days post-implantation (Number of affected animals) a Physical deterioration after 36 days post-implantation (Number of affected animals) a Incidence (%) b
Piloerection Ulcers Fallen hind legs Bending Bending
PBS 1X 2/10 2/10 3/10 1/10 3/10 40 40 40 40 40
CIGB-552 (1 mg/kg) 1/10 1/10 - - - 10 * 10 * 10 * 10 * 10 *
CDDP (0.4 mg/kg) 1/10 1/10 4/10 2/10 1/10 50 50 50 50 50
CIGB-552 (1 mg/kg) + CDDP (0.4 mg/kg) - - - - - 0 * 0 * 0 * 0 * 0 *
a Number of animals with each symptom/ total) ; b Number of animals with one or more symptoms/ total (in %); * p < 0.05 compared to the CDDP treated group (One way Anova and Dunnet post test) a Number of animals with each symptom/ total) ; b Number of animals with one or more symptoms/ total (in %); * p < 0.05 compared to the CDDP treated group (One way Anova and Dunnet post test) a Number of animals with each symptom/ total) ; b Number of animals with one or more symptoms/ total (in %); * p < 0.05 compared to the CDDP treated group (One way Anova and Dunnet post test) a Number of animals with each symptom/ total) ; b Number of animals with one or more symptoms/ total (in %); * p < 0.05 compared to the CDDP treated group (One way Anova and Dunnet post test) a Number of animals with each symptom/ total) ; b Number of animals with one or more symptoms/ total (in %); * p < 0.05 compared to the CDDP treated group (One way Anova and Dunnet post test) a Number of animals with each symptom/ total) ; b Number of animals with one or more symptoms/ total (in %); * p < 0.05 compared to the CDDP treated group (One way Anova and Dunnet post test) a Number of animals with each symptom/ total) ; b Number of animals with one or more symptoms/ total (in %); * p < 0.05 compared to the CDDP treated group (One way Anova and Dunnet post test) a Number of animals with each symptom/ total) ; b Number of animals with one or more symptoms/ total (in %); * p < 0.05 compared to the CDDP treated group (One way Anova and Dunnet post test) a Number of animals with each symptom/ total) ; b Number of animals with one or more symptoms/ total (in %); * p < 0.05 compared to the CDDP treated group (One way Anova and Dunnet post test) a Number of animals with each symptom/ total) ; b Number of animals with one or more symptoms/ total (in %); * p < 0.05 compared to the CDDP treated group (One way Anova and Dunnet post test)