This is an experimental animal study and small number of subjects is the
main limitation due to ethics considerations. Although we had used
pioglitazone and ILE at doses used in the previous animal studies, they
may not be effective in order to demonstrate our hypothesis. We had
evaluated the tissue effects after 24 hours. This time period may not be
enough for histopathological changes to be observed especially for the
heart. As also mentioned in the previous studies, ILE administration may
prevent biochemical parameters from being measured accurately.
Therefore, we could not say anything about molecular based changes in
the blood in terms of organ functions.