According to our results, acute pioglitazone intoxication with 1000mg/kg
may cause histopathological changes in renal and liver tissues in rats
and ILE is not effective in reversing these unwanted effects. Our
results also showed that acute intoxications with that given dose may
not cause cardiac myocyte changes. Another important result of our study
is that ILE itself may be toxic for renal tissues.Conflicts of Interest: The authors declare that they have no
conflict of interest.Funding: This work was supported by the University of Health
Science, Istanbul, Turkey (grant number 2018/084).