32 rats in the 4 groups in our study were followed 24 hours after the
drug and fluid administrations. All the animals had free access to food
and water. After 24 hours, mice were sacrificed by cervical dislocation.
No rats were lost during this period. Heart, liver and kidneys were
dissected and subjected to histopathological examination. Group 1 was
determined as the control group.
Histopathological scoring results were obtained according to microscopic
examination of liver tissues. Figure 1 represents the microscopic views
of the hepatic tissues. Comparison of histopathological scores of liver
tissues between groups are shown in figure 2. There was no statistically
significant difference between 1st (control) and
2nd (ILE) groups in terms of histopathological
scoring. 3rd (PIO) and 4th (PIO+ILE)
groups showed a statistically significant increase in histopathological
scoring compared to 1st (control) group in terms of
increased tissue damage (p <0.001). There was no statistical
difference between the 3rd (PIO) and
4th (PIO+ILE) groups.
Histopathological scoring results obtained by microscopic examination of
cardiac tissues are shown in Figure 3. Histopathological scores were
higher in group 3 and 4 than in other groups but there was no
statistically significant difference between the groups in terms of
histopathological scoring. Figure 4 shows the comparisons of the results
in terms of cardiac histopathological scoring.
Histopathological scoring results obtained according to microscopic
examination of kidney tissues are shown in Figure 5. The
2nd (ILE), 3rd (PIO) and
4th (PIO+ILE) groups showed a statistically
significant difference in terms of histopathological scoring compared to
the 1st group (control) (p <0.001). There
was no statistically significant difference between
2nd (ILE), 3rd (PIO) and
4th (PIO+ILE) groups. Figure 6 represents the
comparisons among the groups.