6. Conclusion

According to our results, acute pioglitazone intoxication with 1000mg/kg may cause histopathological changes in renal and liver tissues in rats and ILE is not effective in reversing these unwanted effects. Our results also showed that acute intoxications with that given dose may not cause cardiac myocyte changes. Another important result of our study is that ILE itself may be toxic for renal tissues.Conflicts of Interest: The authors declare that they have no conflict of interest.Funding: This work was supported by the University of Health Science, Istanbul, Turkey (grant number 2018/084).