ZnO NPs |
Alginate/acacia |
Rabbits |
Full-thickness excised skin wound |
Possesses good biocompatibility properties; increased deposition of
collagen and calcium, more fibroblasts and few inflammatory cells;
accelerated wound healing |
(Manuja et al., 2020) |
Polycaprolactone (PCL) nanofibers |
Alfalfa |
Human dermal fibroblast and keratinocytes in vitro;
humansand mice |
Ex vivo human skin wound model; mouse excisional wound
splinting model |
Promoted in vitro cellular growth of epidermal
keratinocytes and dermal fibroblasts; promoted wound closure,
re-epithelialization, and granulation tissue formation in mice and human
models |
(Ahn et al., 2019) |
SiNPs
|
Curcumin
|
S. aureus and Pseudomonas aeruginosa biofilms in
vitro
|
Scratch assay on human dermal
fibroblast (HDF) cells
|
Enhanced antimicrobial and antibiofilm activities of curcumin SiNPs as a
photosensitizer in antimicrobial
PDT; showed a narrower denuded region of wounds in a scratch assay
|
(Mirzahosseinipour et al., 2020)
|
SiNPs |
|
PRP and human blood plasma |
|
SiNPs shortened coagulation
time in activated partial
thromboplastin time (APTT) and prothrombin time (PT)tests, increased the
activation of factor X induced by Russell’s viper venom, inhibited the
aggregation of PRP induced by ADP |
(Gryshchuk et al.,
2016) |
Nanobioglass
|
Chitosan hydrogel
|
Rats
|
Liver injury with biopsy
punch; femoral artery injury punctured by needle
|
Formed stable blood clots in vivo; reduced blood clotting time when
added to human whole blood in vitro
|
(Sundaram et al., 2019)
|
AgNPs |
Curcuma |
S. aureus, Streptococcus pyogenes,
E. coli, P. aeruginosa and Candida albicans
|
Scratch assay on fibroblast cells (L929) |
Exhibited remarkable decrease
in the growth of microorganisms; promoted the cell proliferation and
migration in the fibroblast cells |
(Maghimaa et al.,
2020) |
AgNP hydrogels
|
Sodium alginate and gelatin
|
Rats; P. aeruginosa, andS. aureus in vitro
|
Biopsy
punch
|
Showed significant bactericidal activity in vitro; promoted vascular
granulation tissue without cellular fibrous scars and reduced wound size
in vivo
|
(Diniz et al., 2020)
|
GO scaffold |
Fe3O4NPs;
polyhydroxybutyrate-co-hydroxyvalerate copolymer |
Mouse fibroblast
cells in vitro;E. coli, P. aeruginosa, S. aureus and B. subtilis |
Scratch assay on fibroblast cells |
Exhibit efficiency against
gram-negative bacteria strains; significant cell adhesion, proliferation
and accelerated wound contraction |
(Pramanik et al.,
2019) |
TiO2 nanotubes |
IL-4 |
RAW 264.7 murine macrophage
cells |
|
IL-4 was slowly released during the early stage allowing M1
activation, promoted polarization from M1 to M2 macrophages after 72 h |
(Li et al., 2018) |
α-Gal–containing micelle
NPs
|
|
Mice
|
Splinted excisional wound model
|
Enhanced polarization of macrophages toward the M2 healing phenotype,
enhanced granulation tissue deposition, vascular growth and
keratinization
|
(Kaymakcalan et al., 2018)
|
Nanofibrous membrane |
Nanobioglass incorporated chitosan-polyvinyl alcohol (PVA) |
Mice
fibroblast cells; rat traumatic model and mice diabetic model |
Full-thickness wounds |
Upregulated growth factors including VEGF and
TGF-β, downregulated inflammatory cytokines such as TNF-α and IL-1β;
accelerated healing in terms of complete re-epithelialization, improved
collagen alignment and formation of skin appendages |
(Chen et al.,
2019) |
AgNPs |
|
HDFs; human epidermal keratinocytes (HEKs) |
Scratch assay on
HDFs and HEKs |
Downregulated inflammatory cytokines (TNF-α and IL-12)
and MMP3 |
(Frankova et al., 2016) |
AuNPs |
Keratinocyte growth factor |
HDFs and HEKs; rat wounds |
A
full-thickness dorsal excisional wound |
Promoted the proliferation of
keratinocytes and wound closure |
(Pan et al., 2018) |
AuNPs |
Gallic acid, isoflavone and protocatechuic acid isoflavone |
Rats |
Surgical wound |
Suppressed MMP-1 and promoted VEGF,
angiopoietin-2 and collagen, increased dermal and epidermal thickness |
(Lee et al., 2015) |
CONPs |
|
Rabbits |
Rabbit ear hypertrophic scar model after
full-thickness excisional wound |
Improved the collagen arrangement;
reduced scar by inhibiting hypertrophic scar fibroblasts proliferation
and inducing apoptosis |
(Xiao et al., 2019) |