Main outcomes measures:
83 patients with HPSCC in our center, who received IC followed by either CCRT or RT alone according to multidisciplinary team (MDT) discussion, were eligible for analysis. Among these patients, 52 patients underwent CCRT and 31 received RT alone after IC and we compared the two groups. Then we further compared the IC + CCRT and IC+RT groups in IC responders showing complete response (CR) and partial response (PR). Survival, toxicities clinical efficacy and outcomes were analyzed.