Eligibility Criteria:
For inclusion, studies on MR-HIFU treatment of women with clinically symptomatic uterine fibroids were reviewed. Treatment procedures that did not target complete ablation (except for a five-mm protection margin from the serosal surface) or ultrasound-guided HIFU systems were ruled out.
The RCTs, prospective or Retrospective non-randomized, and cross-over studies that considered the treatment of clinically symptomatic uterine fibroids were included. The studies that did not have treatment protocols regarded as complete removal of fibroid or used ultrasound-guided HIFU were excluded. Also, animal studies, case reports, and studies not reporting NPV were excluded.