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\begin{document}

\title{Efficacy of treatments targeting hypothalamic-pituitary-adrenal systems
for major depressive disorder: a meta-analysis}



\author[1]{Yudan Ding}%
\author[1]{Zirou Wei}%
\author[1]{Haohao Yan}%
\author[1]{Wenbin Guo}%
\affil[1]{Second Xiangya Hospital Department of Psychiatry}%


\vspace{-1em}



  
  \date{May 21, 2024}


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\begin{abstract}
Abnormal hypothalamic-pituitary-adrenal (HPA) axis has been implicated
in major depressive disorder (MDD). The aims of this meta-analysis were
to determine the effect and safety profile of HPA-targeting medications
for MDD. World of Science and PubMed databases were comprehensively
searched up to March 2021. All randomized controlled trials (RCTs) and
open-label trials exploring antiglucocorticoid and related medications
in patients with depression were included. In the meta-analysis, we
identified 16 RCTs and seven open-label studies that included 2972
subjects. Our study suggested that patients with MDD may benefit from
mifepristone and V1B receptor antagonist treatments that have tolerable
side effects. HPA-based medications are promising for depression
treatment. However, additional high-quality RCTs, including head-to-head
trials, are needed.%
\end{abstract}%



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\textbf{Hosted file}

\verb`Table 2.docx`  available at \url{https://authorea.com/users/730937/articles/710302-efficacy-of-treatments-targeting-hypothalamic-pituitary-adrenal-systems-for-major-depressive-disorder-a-meta-analysis}

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