Figure 4
NOXA participates in ixazomib induced proliferation inhibition in ESCC
cells. (A) Kyse150 cell treated with or without 1μM ixazomib for 48h.
The expression of ER stress related gene was examined by RT-PCR. (B, C)
After transfected with the NOXA siRNA for 48 h, Kyse150 and Kyse510
cells were further treated with ixazomib (1μmol) for 48 h and the cell
viability and colony formation were examined. Values are the means ± SEM
(n = 5-6). *P < 0.05 or **P < 0.01 indicates
significant differences from the vehicle group as assessed by a
two-tailed unpaired Student’s t test.