SLA: a new tumor immune stimulant
SLA (6ʹ-sulfate-β-D-Galp-(1,4)-β-D-Glcp-(1,1)-archaeol) is a new
formulation of archaeosome, which was first proposed by McCluskie. Its
composition is archaeosome core lipid modified by adding sulfated
saccharide (Fig. 8) [85]. SLA has the characteristics of stabilizing
archaea in extreme environments. Early studies on archaeal membranes
explained the source of archaea. Archaea lack peptidoglycan and
isoprenoid parts are ether connected to the l-glycerol backbone. In
bacteria, esters are linked to fatty acid-derived hydrocarbon chains.
Like liposomes, archaesome can constitute effective carrier vesicles for
entrapped antigens, and the inherent stability and unique structure
enable it more potential to be used as drug delivery carrier.