RESULTS
The rat model development has been confirmed when it mimicked the clinical pathophysiology of futuristic PTE in Wistar rats (200-250 grams). The brass weight of 500 grams was dropped over the exposed skull from the height of 1.4 meters. This impact generated 0.70 joules of force which gives a moderate type of primary injury in the head. The initial brain insult exacerbated the epileptogenesis cascade in the form of secondary injury by lowering the seizure threshold in the Wistar rats and they became susceptible to the first successive seizure with a sub-convulsive dose of PTZ(35mg/kg).