Background
Nocturnal enuresis is a common symptom in children with sickle cell
disease (SCD). Risk factors for development of enuresis are currently
unknown. An early manifestation of SCD-associated kidney damage is
glomerular hyperfiltration. We test the hypothesis that in a pediatric
SCD cohort, individuals with hyperfiltration are more likely to have
nocturnal enuresis when compared to children without hyperfiltration.