Impact of Current Enuresis on long term outcomes:
We performed repeated data analysis to determine the impact of currently having enuresis on longitudinal kidney outcomes using a GEE approach. In a univariate analysis, children with current enuresis had increased odds of having sickle cell anemia (OR: 2.33 95% CI: 1.02-5.34, p=0.045). Children with current enuresis were identified with higher odds of having higher eGFR values (OR 1.07, CI 1.1-1.12, p=0.014) and categorized as having hyperfiltration (OR 1.01, CI 1.0-1.02, p=0.038) (Figure 2) when adjusted for age and sex in the model. When SCD type was added to the model of age and sex, the association between current enuresis and either eGFR or hyperfiltration (eGFR: OR: 1.05, 95% CI: 0.99-1.10, p=0.085; hyperfiltration: OR: 1.01, 95%CI: 1.00-1.02, p=0.11) was no longer statistically significant. Children with current enuresis maintained an average lower hemoglobin and an average higher LDH over time (OR: 0.92, CI: 0.85-0.98, p=0.016 and OR 1.03, CI: 1.01-1.06, p=0.0017), which remained significant after adjusting for age and sex (OR:0.91, CI: 0.84-0.99, p=0.027 and OR 1.03, CI:1.01-1.06, p=0.0048, respectively). Again, when including SCD type in the GEE model, this association was no longer significant.