2.15. Xenograft tumor growth
The SUDHL4 xenograft tumour models were developed by injecting 1 ×
107 cells into male SCID mice (6-8 weeks of age). The
mice were grouped randomly when the volume of the tumour nodules reached
100 mm3 and were treated by gavage injection with the
indicated compounds or vehicle for 18 days, and the bodyweight and
tumour dimensions were measured. The tumour volume was calculated using
the following equation: tumour volume = length × width × width × 0.52.
At the completion of the study, the mice were euthanized, and tumours
and major organs were collected.