Effects of L-Carnitine supplementation on the clinical outcomes and 28-day mortality
A significant decrease was observed in SOFA score during the LC intervention (P<0.001), while no significant change was observed in placebo group (P=0.08) and the mean decrease over the study period was statistically significant in LC group compared to placebo group (P=0.021) [Figure2]. The APACHE score was significantly decreased in LC group (P<0.001), it was significantly increased in the placebo group and the mean decrease was statistically and clinically significant in LC group compared to placebo group (P=0.001) (Table 3). The 28-day mortality rate was significantly lower in LC group compared to the placebo group (29.2% VS 59.3%, P=0.048). Although we did not observe significant difference in the duration of hospital and ICU stay between two groups, however the observed difference were clinically notable. we found a significant decrease in duration of mechanical ventilation in LC group compared with the placebo group and also ICU discharge was significantly shorter in the LC group compared with placebo group (Table 4).