Effects of L-Carnitine supplementation on the clinical
outcomes and 28-day mortality
A significant decrease was observed in SOFA score during the LC
intervention (P<0.001), while no significant change was
observed in placebo group (P=0.08) and the mean decrease over the study
period was statistically significant in LC group compared to placebo
group (P=0.021) [Figure2]. The APACHE score was significantly
decreased in LC group (P<0.001), it was significantly
increased in the placebo group and the mean decrease was statistically
and clinically significant in LC group compared to placebo group
(P=0.001) (Table 3). The 28-day mortality rate was significantly lower
in LC group compared to the placebo group (29.2% VS 59.3%, P=0.048).
Although we did not observe significant difference in the duration of
hospital and ICU stay between two groups, however the observed
difference were clinically notable. we found a significant decrease in
duration of mechanical ventilation in LC group compared with the placebo
group and also ICU discharge was significantly shorter in the LC group
compared with placebo group (Table 4).