CONCLUSION
In this study we present encouraging data on improved survival in
immunosuppressed children with AIFR. While still considered one of the
deadliest infectious diseases in this population, we observed that low
threshold for investigation, utilization of PCR for fungal detection,
treatment with novel antifungal agents combined with rapid and
aggressive surgical treatment and better control over the underlying
oncological disease, dramatically reduced AIFR mortality rates. We
suggest that panfungal PCR should have an increasing role in the
detection of fungal pathogens and that novel antifungal drugs should
become an essential part of the treatment regimen.