Serelaxin attenuated the CFs proliferation induced by LPS
The CCK-8 assay was used to measure proliferation of the CFs. As shown in Figure 2, The proliferation of CFs was induced by the LPS stimulation. Compared with the control group, the OD values were significantly higher in the LPS group (P < 0.05). However, compared with the LPS group, CCK-8 assay showed that the OD values in the serelaxin treated group were decreased markedly. Further analysis showed that GW9662 could reverse the inhibitory effect of serelaxin and increase the proliferation of CFs.