PPARγ inhibitor reversed the anti-inflammatory effects of
serelaxin
In order to prove the anti-inflammatory mechanism of serelaxin, PPARγ
was inhibited by GW9662. As shown in Fig.7, GW9662 significantly
inhibited the expression of PPARγ. However, inhibitory effect of
serealxin on IL-1β, IL-6 and TNF-α was reversed by GW9662(Fig. 5). These
results demonstrated that serelaxin exerts an anti-inflammatory effect
by activating PPARγ pathway.