3.2. Fer-1 hardly affects epileptic progression in PTE mice model
Next, we wondered whether Fer-1 blocked epileptogenic progression in PTE
mice model. On the day 19 after FeCl3 injection, we
monitored EEG for three consecutive days. The recurrent epileptic
seizures were observed in mice with PTE (Figure 3A). However, treatment
with Fer-1 was found to hardly influence EEG power per day (Figure 3B),
total power (Figure 3C) and spikes (Figure 3D). In addition, seizures
per day for each mouse in the chronic stage of PTE and cumulative
spontaneous recurrent seizure (SRS) duration were also not different
between Vehicle- and Fer-1-treated PTE mice (Figure 3E and Figure 3F).
Collectively, these findings suggest that Fer-1 has little effect on the
epileptogenesis.