Results
From December 1, 2018 to November 30, 2020, there were 3460 patients
with acute ICH enrolled in the CHEERY study and 3260 patients were
included in the final analysis (figure 1). The demographic data were
listed in table 1.
Patients’ average age was 61.9±12.3 during COVID-19 pandemic and
60.5±12.5 before COVID-19 breakout (P=0.001), respectively. COVID-19
pandemic was associated with lower percentage of the male (P=0.002),
history of smoking (P=0.001) and drinking (P=0.017) (table 1).
During COVID-19 pandemic, patients more likely went to hospital directly
by themselves (P<0.001), and took less time from the onset to
admission (4(2,12) vs. 6(2,24) h, P<0.001) compared with
before COVID-19. COVID-19 pandemic was also associated with increase of
systolic blood pressure (BP) (171.3±29.2 vs. 164.3±28.7 mmHg,
P<0.001), diastolic-BP (97.6±16.9 vs. 95.7±17.6 mmHg,
P=0.002), NIHSS score (11.6±10.5 vs. 10.8±10.0, P=0.039), deep ICH (81%
vs. 77%, P=0.010), hematoma volume (11.0(5.0,27.0) vs.
10.0(4.6,20.9)ml, P=0.009), IVH (16% vs. 14%, P=0.021) and fasting
blood glucose (6.2(5.2,7.8) vs. 6.1(5.3,7.3) mmol/L, P=0.003) on
admission (table 1). At 3 month, mRS score distribution was shown in
figure 2. The three-month mortality was 23%, much higher than that of
last year (14%) (P<0.001).
We then comparatively evaluated the outcomes. Table 2 shows COVID-19
pandemic was associated with increased risk of 3-month poor outcome (ORunadjusted = 1.244, 95%CI: 1.078-1.436; ORadjusted = 1.206, 95%CI: 1.043-1.395) and 3-month
mortality (OR unadjusted = 1.772, 95%CI: 1.481-2.120;
OR adjusted = 1.711, 95%CI: 1.428-2.050).