Figure 6. Multiple alignment plot of the four Ion Transport domain sequences previously studied by Venkatesh et al., 2005, fromLatimeria chalumnae (NaV1.4), Lepisosteus oculatus(NaV1.4), Callorhinchus milii (NaV1.4), T. pardalis(NaV1.4a), T. rubripes (NaV1.4a, NaV1.4b), T. nigroviridis(NaV1.4a, NaV1.4b), L. sceleratus (NaV1.4a, NaV1.4b), M. mola (NaV1.4a, NaV1.4b), S. aurata (NaV1.4a, NaV1.4b), O. latipes (NaV1.4a, NaV1.4b), M. morhua (NaV1.4a, NaV1.4b) andD. rerio (NaV1.4a, NaV1.4b). Residues outlined in red, have been previously associated with TTX resistance in T. rubripes and T. nigroviridis by Venkatesh et al., 2005.