Serious adverse events:
All serious adverse events were reported by both studies regardless of
the trials authors’ judgement on if the event was related to the
treatment or not.
Total number of SAE was 72 events in 55 (21%) patients out of 261
patients for the Cryoablation group and 110 events in 88 patients (34%)
out of 260 patients for the AAD group.
The meta-analysis generated, a pooled RR for overall SAE of 0.66 for CA
Versus (95% CI 0.46, 0.95, P = 0.03, I2=56%) using the random effect
model, out of the two included studies (n=521) (fig. 2)
The meta-analysis generated, a pooled RR for overall patients with a
minimum of 1 SAE of 0.62 for CA Versus AAD (95% CI 0.47, 0.83, P=0.001,
I2=0%) using the fixed effect model, out of the two included studies
(n=521) (fig. 3)
No mortalities were reported in either of the studies.